ArticleDevelopment and psychopathology2020
Sleep problems in adolescence are prospectively linked to later depressive symptoms via the cortisol awakening response.
Article in Development and psychopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- The Influence of Exercise on the Endocrine System: Impacts on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Associations between affect variability, mean affect, and mental health among college students during the COVID-19 pandemic.Journal of American college health : J of ACH · 2025Article
- Barriers to mental health services among at-risk and symptomatic adolescents in the community.Child and adolescent psychiatry and mental health · 2025Article
- Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder.Comprehensive psychoneuroendocrinology · 2025Article
- Interconnected struggles: How insomnia, anxiety, and depression impact mental health.World journal of psychiatry · 2025Article
- The association of chronotype on depression in adolescents: the mediating role of sensation seeking and sleep quality.BMC psychiatry · 2025Article
- Effect of insomnia on anxiety and depression: Mediation of cognitive failures and moderated mediation of neuroticism.World journal of psychiatry · 2025Article
- Within-person reciprocal links between stress, sleep, and depressive symptoms across Latino/a adolescents' transition to and through college.Development and psychopathology · 2025Article
- Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures.World journal of psychiatry · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
- Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.Psychoneuroendocrinology · 2025Article
- Give me five! A modern perspective on addiction from the up-dated Freudian drive theory.Frontiers in psychiatry · 2025Article
- Implications of childhood adversity for women's perinatal sleep quality and depressive symptoms over time: A serial mediation model.Journal of sleep research · 2024Article
- Characteristics of the oral microbiome in youth exposed to caregiving adversity.Brain, behavior, & immunity - health · 2024Article
- Sleep quality and the cortisol and alpha-amylase awakening responses in adolescents with depressive disorders.BJPsych open · 2024Article
- From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review.Psychoneuroendocrinology · 2023Article
- The Relationship between Insomnia and the Pathophysiology of Major Depressive Disorder: An Evaluation of a Broad Selection of Serum and Urine Biomarkers.International journal of molecular sciences · 2023Article
- Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents.Frontiers in sleep · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Sleep disturbance is a symptom of and a well-known risk factor for depression. Further, atypical functioning of the HPA axis has been linked to the pathogenesis of depression. The purpose of this study was to examine the role of adolescent HPA axis functioning in the link between adolescent sleep problems and later depressive symptoms. Methods: A sample of 157 17-18 year old adolescents (61.8% female) completed the Pittsburgh Sleep Quality Inventory (PSQI) and provided salivary cortisol samples throughout the day for three consecutive days. Two years later, adolescents reported their depressive symptoms via the Center for Epidemiological Studies Depression Scale (CES-D). Results: Individuals (age 17-18) with greater sleep disturbance reported greater depressive symptoms two years later (age 19-20). This association occurred through the indirect effect of sleep disturbance on the cortisol awakening response (CAR) (indirect effect = 0.14, 95%CI [.02 -.39]). Conclusions: One pathway through which sleep problems may lead to depressive symptoms is by up-regulating components of the body's physiological stress response system that can be measured through the cortisol awakening response. Behavioral interventions that target sleep disturbance in adolescents may mitigate this neurobiological pathway to depression during this high-risk developmental phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.