ArticleWorld journal of surgical oncology2019
AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN.
Article in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- [Malignant Pancreatic Intraductal Papillary Mucinous Neoplasm with Splenic Invasion: A Case Report].Journal of the Korean Society of Radiology · 2024Article
- The prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma.World journal of surgical oncology · 2023Review
- Prognostic Analysis of Different Metastatic Patterns in Invasive Intraductal Papillary Mucinous Neoplasm: A Surveillance, Epidemiology, and End Results Database Analysis.Canadian journal of gastroenterology & hepatology · 2021Article
- Validation of American Joint Committee on Cancer 8World journal of gastrointestinal pharmacology and therapeutics · 2020Article
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10 authors at 3 institutions in 1 country.
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Abstract
backgroundBoth the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging systems have been introduced for pancreatic adenocarcinoma. However, the applicability of these classifications for invasive intraductal papillary mucinous neoplasms (IPMN) has not been systematically examined.
methodsPatients with invasive IPMN were retrieved from a cohort of 18 geographical sites (1973-2014 varying) in the Surveillance, Epidemiology, and End Results (SEER) cancer registry. The 7th and 8th editions of the AJCC staging were compared. Survival rates and multivariate analyses were computed.
resultsIn total, 1216 patients with resected invasive IPMN were included. A major difference between the 7th and 8th systems is the definition of stage IIA (7th, beyond the pancreas without involvement of major arteries; 8th, maximum tumor diameter > 4 cm). The hazard ratio (HR) of stage IIA disease (versus stage IA, HR = 2.33, P < 0.001) was higher than that of stage IB disease (HR = 1.48, P = 0.087) by the 7th edition classification, whereas the HR of stage IIA disease (HR = 1.26, P = 0.232) was even lower than that of stage IB disease (HR = 1.48, P = 0.040) by the 8th edition classification. In addition, for the 8th edition staging system, tumor size was not a predictor of survival in patients with resectable tumor > 2 cm (size > 4 cm versus > 2 ≤ 4 cm, HR = 0.91, P = 0.420).
conclusionsThe AJCC 7th edition staging classification is more applicable than the 8th edition classification for invasive IPMN.
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