Evidence map›Paper›PMID 31387604›Full record

ArticleJournal of nanobiotechnology2019

Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8

Laura Sanz-Ortega, Yadileiny Portilla, Sonia Pérez-Yagüe, Domingo F Barber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura Sanz-OrtegaDepartment of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Yadileiny PortillaDepartment of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Sonia Pérez-YagüeDepartment of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Domingo F BarberDepartment of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain. dfbarber@cnb.csic.es.ORCID http://orcid.org/0000-0001-8824-5405
Centro Nacional de Biotecnología · ES

Funding

Spanish Ministry of Economy, Industry and Competitiveness FPU13/05037Spanish Ministry of Economy, Industry and Competitiveness FPU15/06170Spanish Ministry of Economy, Industry and Competitiveness SAF-2014-54057-RSpanish Ministry of Economy, Industry and Competitiveness SAF-2017-82223-R
6 · The paper itself

Abstract

backgroundAdoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a small proportion reaching the tumour. To remedy this, magnetic targeting of T cells has been recently explored. Magnetic nanoparticles (MNPs) functionalised with antibodies were attached to effector T cells and magnetically recruited to tumour sites under MRI guidance. In this study, we investigated whether 3-aminopropyl-triethoxysilane (APS)-coated MNPs directly attached to CD8

resultsFirst, we show that antigen-specific CD8

conclusionsThe use of an EMF to improve targeting of tumour-specific T cells modified with APS-MNPs reduced the percentage of these cells infiltrating the tumour, but promoted the retention and the persistence of these cells in the tumour-draining LNs.

Indexed as

Adoptive TransferAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell Membrane PermeabilityCell ProliferationCell SurvivalFemaleLymph NodesLymphocyte ActivationLymphocytes, Tumor-InfiltratingMagnetite NanoparticlesMice, Inbred C57BLNeoplasms, ExperimentalNeoplasm TransplantationPropylaminesamino-propyl-triethoxysilaneMagnetite NanoparticlesPropylaminesSilanesCancer immunotherapyCell-based therapyEffector T cellMagnetic nanoparticleMagnetic retention

Identifiers

PMID31387604
PMCPMC6683429
OpenAlexW2965781485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.