ArticleProceedings. Biological sciences2019
New ways to acquire resistance: imperfect convergence in insect adaptations to a potent plant toxin.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Fecal Deployment: An Alternative Way of Defensive Host Plant Cardenolide Use by Lilioceris merdigera Larvae.Journal of chemical ecology · 2024Article
- Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistance strategies.Current biology : CB · 2023Article
- Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistance strategies.bioRxiv : the preprint server for biology · 2023Article
- Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases.Molecular biology and evolution · 2022Article
- RETRACTED: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence.PLoS genetics · 2022Article
- Na,K-ATPase α1 and β-subunits show distinct localizations in the nervous tissue of the large milkweed bug.Cell and tissue research · 2022Article
- Dietary cardenolides enhance growth and change the direction of the fecundity-longevity trade-off in milkweed bugs (Heteroptera: Lygaeinae).Ecology and evolution · 2021Article
- Wing Musculature Reconstruction in Extinct Flightless Auks (Integrative organismal biology (Oxford, England) · 2021Article
- New ways to acquire resistance: imperfect convergence in insect adaptations to a potent plant toxin.Proceedings. Biological sciences · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Evolution of insensitivity to the toxic effects of cardiac glycosides has become a model in the study of convergent evolution, as five taxonomic orders of insects use the same few similar amino acid substitutions in the otherwise highly conserved Na,K-ATPase α. We show here that insensitivity in pyrgomorphid grasshoppers evolved along a slightly divergent path. As in other lineages, duplication of the Na,K-ATPase α gene paved the way for subfunctionalization: one copy maintains the ancestral, sensitive state, while the other copy is resistant. Nonetheless, in contrast with all other investigated insects, the grasshoppers' resistant copy shows length variation by two amino acids in the first extracellular loop, the main part of the cardiac glycoside-binding pocket. RT-qPCR analyses confirmed that this copy is predominantly expressed in tissues exposed to the toxins, while the ancestral copy predominates in the nervous tissue. Functional tests with genetically engineered Drosophila Na,K-ATPases bearing the first extracellular loop of the pyrgomorphid genes showed the derived form to be highly resistant, while the ancestral state is sensitive. Thus, we report convergence in gene duplication and in the gene targets for toxin insensitivity; however, the means to the phenotypic end have been novel in pyrgomorphid grasshoppers.
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