ArticleBiology letters2019
Optimization of circadian responses with shorter and shorter millisecond flashes.
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Circadian and photoperiodic control of melatonin inBiochemistry and biophysics reports · 2025Article
- A millisecond parameter space for phase-shifting the circadian pacemaker with near-ultraviolet light.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Moving time zones in a flash with light therapy during sleep.Scientific reports · 2023Article
- Article
- Spectrophotometric properties of commercially available blue blockers across multiple lighting conditions.Chronobiology international · 2022Article
- Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes.Proceedings. Biological sciences · 2022Article
- Circadian Responses to Light-Flash Exposure: Conceptualization and New Data Guiding Future Directions.Frontiers in neurology · 2021Article
- Suppression of Circadian Timing and Its Impact on the Hippocampus.Frontiers in neuroscience · 2021Review
- Time-Varying Light Exposure in Chronobiology and Sleep Research Experiments.Frontiers in neurology · 2021Review
- Removing Short Wavelengths From Polychromatic White Light Attenuates Circadian Phase Resetting in Rats.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent work suggests that the circadian pacemaker responds optimally to millisecond flashes of light, not continuous light exposure as has been historically believed. It is unclear whether these responses are influenced by the physical characteristics of the pulsing. In the present study, Drosophila (n = 2199) were stimulated with 8, 16 or 120 ms flashes. For each duration, the energy content of the exposure was systematically varied by changing the pulse irradiance and the number of stimuli delivered over a fixed 15 min administration window (64 protocols surveyed in all). Results showed that per microjoule invested, 8 ms flashes were more effective at resetting the circadian activity rhythm than 16- and 120 ms flashes (i.e. left shift of the dose-response curve, as well as a higher estimated maximal response). These data suggest that the circadian pacemaker's photosensitivity declines within milliseconds of light contact. Further introduction of light beyond a floor of (at least) 8 ms leads to diminishing returns on phase-shifting.
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