Evidence map›Paper›PMID 31387346›Full record

ArticleACS chemical neuroscience2019

Designing Functionally Selective Noncatechol Dopamine D

Michael L Martini, Caroline Ray, Xufen Yu, Jing Liu, Vladimir M Pogorelov, William C Wetsel, Xi-Ping Huang, John D McCorvy, Marc G Caron, Jian Jin

Erratum issuedAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021
    Pooled it
  2. Article
  3. Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025
    Review
  4. Article
  5. Estimation of Dopamine DACS chemical neuroscience · 2025
    Article
  6. Characterization of GαiScience · 2025
    Article
  7. Article
  8. Article
  9. Role of dopamine agonists in Parkinson's disease therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  10. Article
  11. Umpolung Synthesis of Pyridyl Ethers by BiAngewandte Chemie (International ed. in English) · 2022
    Article
  12. Article
  13. α-Arrestins and Their Functions: From Yeast to Human Health.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Michael L MartiniMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Caroline RayDepartment of Cell Biology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Xufen YuMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Jing LiuMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Vladimir M PogorelovDepartment of Cell Biology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
William C WetselDepartment of Cell Biology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Xi-Ping HuangDepartment of Pharmacology and National Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
John D McCorvyDepartment of Cell Biology, Neurobiology and Anatomy , Medical College of Wisconsin , Milwaukee , Wisconsin 53226 , United States.
Marc G CaronDepartment of Cell Biology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Jian JinMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.ORCID 0000-0002-2387-3862
Duke University · USIcahn School of Medicine at Mount Sinai · USMedical College of Wisconsin · USUniversity of North Carolina at Chapel Hill · US

Funding

MOUNT SINAI MEDICAL SCIENTIST TRAINING PROGRAMT32GM007280 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 1985 to 2021
$22.8M
Teaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2M
Exploiting Dopamine Receptor Functional Selectivity as an Approach to Treat Parkinson's SymptomsR01NS100930 · NINDS · DUKE UNIVERSITY · PI CARON, MARC G. · 2017 to 2021
$3.2M
Beta-Arrestin-Biased Agonism at the D1 Receptor as a Novel Approach to Levodopa-Induced Dyskinesias in Advanced Parkinson's DiseaseF30AG062054 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARTINI, MICHAEL LOUIS · 2019 to 2020
$89k
NIA NIH HHS F30 AG062054NIGMS NIH HHS T32 GM007280NIGMS NIH HHS T32 GM062754NINDS NIH HHS R01 NS100930
6 · The paper itself

Abstract

Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D

Indexed as

AnimalsAntiparkinson AgentsArrestinsCyclic AMPDopamineDopamine AgonistsReceptors, Dopamine D1Receptors, Dopamine D2Receptors, G-Protein-CoupledAntiparkinson AgentsArrestinsCyclic AMPDopamineDopamine AgonistsReceptors, Dopamine D1Receptors, Dopamine D2Receptors, G-Protein-Coupledbiased agonismD dopamine receptordyskinesianoncatechol agonistsParkinson’s diseasestructure−functional selectivity relationshipβ-arrestins

Identifiers

PMID31387346
PMCPMC6785188
OpenAlexW2965382783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.