ArticleAntioxidants (Basel, Switzerland)2019
Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea.
Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
- Trial
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- Association Between Selected Flavanols and Isoflavones and Precocious Puberty in Girls-A Scoping Review.Nutrients · 2026Article
- Targeting neuroimmune interactions: the therapeutic potential of kaempferol in immune-related central nervous system disorders.Frontiers in immunology · 2026Review
- Kaempferol Inhibits Colonic Contractions via L‑Type Voltage-Dependent Calcium Channels in Murine Smooth Muscle Cells.ACS omega · 2025Article
- Multiple Demographic, Lifestyle, and Biological Factors Associated With Brain Iron Deposition in the Basal Ganglia: A Comprehensive Analysis of 25,980 UK Biobank Participants.Brain and behavior · 2025Article
- Green Tea: Current Knowledge and Issues.Foods (Basel, Switzerland) · 2025Review
- Insights into rutin and quercetin biotransformations in ruminants revealed by molecular networking.Journal of animal science · 2025Article
- Investigation of Tongqiao Huashuan Granules' effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and experimental validation.Frontiers in neurology · 2025Article
- Study on the degradation pathway of benzo[a]pyrene byFrontiers in microbiology · 2025Article
- Bioaccessibility of Flavones, Flavanones, and Flavonols from Vegetable Foods and Beverages.Biology · 2024Article
- Potentialities of Tannase-Treated Green Tea Extract in Nutraceutical and Therapeutic Applications.Applied biochemistry and biotechnology · 2024Review
- Valorizing Tea Waste: Green Synthesis of Iron Nanoparticles for Efficient Dye Removal from Water.Antioxidants (Basel, Switzerland) · 2024Article
- Regular Consumption of Green Tea as an Element of Diet Therapy in Drug-Induced Liver Injury (DILI).Nutrients · 2024Review
- Integrated Untargeted Metabolome, Full-Length Sequencing and Transcriptome Analyses Reveal the Mechanism of Flavonoid Biosynthesis in Blueberry (International journal of molecular sciences · 2024Article
- Therapeutic potentialities of green tea (Camellia sinensis) in ischemic stroke: biochemical and molecular evidence.Metabolic brain disease · 2024Review
- Varietal Authenticity Assessment of QTMJ Tea Using Non-Targeted Metabolomics and Multi-Elemental Analysis with Chemometrics.Foods (Basel, Switzerland) · 2023Article
- Non-targeted metabolomics characterization of flavor formation of Lichuan black tea processed from different cultivars in Enshi.Food chemistry: X · 2023Article
- Bidirectional Interactions between Green Tea (GT) Polyphenols and Human Gut Bacteria.Journal of microbiology and biotechnology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
(1) Background: Extensive research has focused on flavan-3-ols, but information about the bioactivities of green tea flavonols is limited. (2) Methods: In this study, we investigated the antioxidative, anti-inflammatory, and anticancer effects of flavonol glycosides and aglycones from green tea using in vitro cell models. The fractions rich in flavonol glycoside (FLG) and flavonol aglycone (FLA) were obtained from green tea extract after treatment with tannase and cellulase, respectively. (3) Results: FLG and FLA contained 16 and 13 derivatives, respectively, including apigenin, kaempferol, myricetin, and quercetin, determined by mass spectrometry. FLA exhibited higher radical-scavenging activity than that of FLG. FLG and FLA attenuated the levels of intracellular oxidative stress in neuron-like PC-12 cells. The treatment of RAW 264.7 murine macrophages with FLG and FLA significantly reduced the mRNA expression of inflammation-related genes in a dose-dependent manner. Furthermore, FLG and FLA treatments decreased the viability of the colon adenoma cell line DLD-1 and breast cancer cell line E0771. Moreover, the treatment with FLG or FLA combined with paclitaxel had synergistic anticancer effects on the DLD-1 cell line. (4) Conclusions: Flavonols from green tea exerted beneficial effects on health and may be superior to flavan-3-ols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.