ArticleInvestigative ophthalmology & visual science2019
Impaired Fellow Eye Motion Perception and Abnormal Binocular Function.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226141 (Valproate for the Treatment of Residual Amblyopia), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Valproate for the Treatment of Residual Amblyopia
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Short-Term Axial Length Effects of Combining Paracentral Collimating Apertures with Near-Peripheral Myopic Defocus for Myopia Control.Journal of clinical medicine · 2026Article
- Spatiotemporal Dynamics of Binocular Interaction in Anisometropic Amblyopia Revealed by Classification Image.Investigative ophthalmology & visual science · 2026Article
- Regaining Visual Acuity Does Not Restore Motion Extrapolation Deficits in Amblyopia.Investigative ophthalmology & visual science · 2025Article
- Binocular and Fellow Eye Acuity Deficits in Amblyopia: Impact of Fixation Instability and Sensory Factors.Journal of eye movement research · 2025Article
- Monocular Contrast Sensitivity Visual Perceptual Learning Rebalances Adult Amblyopes' Two Eyes.Investigative ophthalmology & visual science · 2025Article
- Poor fixation stability does not account for motion perception deficits in amblyopia.Scientific reports · 2025Article
- Biometric parameters and choroidal microstructure in Chinese children with unilateral anisometropia.Frontiers in medicine · 2025Article
- Motion-Defined Form Perception in Deprivation Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Amblyopia and the whole child.Progress in retinal and eye research · 2023Review
- Binocular amblyopia treatment improves manual dexterity.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Article
- Assessment of corneal biomechanics in anisometropia using Scheimpflug technology.Frontiers in bioengineering and biotechnology · 2022Article
- Delayed Correction for Extrapolation in Amblyopia.Investigative ophthalmology & visual science · 2021Article
- Orienting of covert attention by neutral and emotional gaze cues appears to be unaffected by mild to moderate amblyopia.Journal of vision · 2021Article
- The Flash-lag Effect in Amblyopia.Investigative ophthalmology & visual science · 2021Article
- Stimuli Characteristics and Psychophysical Requirements for Visual Training in Amblyopia: A Narrative Review.Journal of clinical medicine · 2020Review
- Associations of Eye-Related Quality of Life With Vision, Visuomotor Function, and Self-Perception in Children With Strabismus and Anisometropia.Investigative ophthalmology & visual science · 2020Article
- Suppression Rather Than Visual Acuity Loss Limits Stereoacuity in Amblyopia.Investigative ophthalmology & visual science · 2020Article
- Leveraging neural plasticity for the treatment of amblyopia.Survey of ophthalmologyReview
- Fellow Eye Deficits in Amblyopia.Journal of binocular vision and ocular motilityReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Purpose: Binocular discordance due to strabismus, anisometropia, or both may result in not only monocular visual acuity deficits, but also in motion perception deficits. We determined the prevalence of fellow-eye deficits in motion-defined form (MDF) perception, the ability to identify a two-dimensional (2D) shape defined by motion rather than luminance contrast. We also examined the following: the causative role of reduced visual acuity and binocularity, associations with clinical and sensory factors, and effectiveness of binocular amblyopia treatment in alleviating deficits. Methods: Participants included 91 children with residual amblyopia (strabismic, anisometropic, or both; age, 9.0 ± 1.7 years), 79 nonamblyopic children with treated strabismus or anisometropia (age, 8.5 ± 2.1 years), and 20 controls (age, 8.6 ± 1.5 years). MDF coherence thresholds, visual acuity, stereoacuity, and interocular suppression were measured. Results: MDF deficits, relative to controls, were present in the fellow eye of 23% of children with residual amblyopia and 20% of nonamblyopic children. Stereoacuity and age first patched were correlated with MDF threshold (r = 0.29, 95% CI: 0.09-0.47; r = -0.33, 95% CI: -0.13 to -0.50, respectively). MDF deficits were more common in children treated with patching alone than in those receiving contrast-rebalanced binocular treatment with games or movies (t89 = 3.46; P = 0.0008). The latter was associated with a reduction in mean fellow eye MDF threshold (t26 = 6.32, P < 0.0001). Conclusions: Fellow eye MDF deficits are common and likely reflect abnormalities in binocular cortical mechanisms that result from early discordant visual experience. Binocular amblyopia treatment, which is effective in improving amblyopic eye visual acuity, appears to provide a benefit for the fellow eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.