Evidence map›Paper›PMID 31386859›Full record

ArticleDevelopmental cell2019

Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering.

Alyssa M English, Adam L Hughes

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Mitochondrial signal transduction.Cell metabolism · 2022
    Review
  2. The multi-faced role of FUNDC1 in mitochondrial events and human diseases.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alyssa M EnglishDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Adam L HughesDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: hughes@biochem.utah.edu.
University of Utah · US

Funding

Regulation of Mitochondrial HomeostasisR35GM119694 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Adam Hughes · 2016 to 2026
$4.2M
The Role of the Lysosome in AgingR01AG061376 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Adam Hughes · 2018 to 2026
$3.3M
NIA NIH HHS R01 AG061376NIGMS NIH HHS R35 GM119694
6 · The paper itself

Abstract

In this issue of Developmental Cell, Wong et al. (2019) show that the lysosomal GTPase Rab7 regulates inter-mitochondrial contacts to control mitochondrial motility and identify dysregulated inter-mitochondrial tethering as a common theme in Charcot-Marie-Tooth (CMT) type 2 disease.

Indexed as

Charcot-Marie-Tooth DiseaseDiabetes Mellitus, Type 2GTP PhosphohydrolasesHumansLysosomesMitochondriaGTP Phosphohydrolases

Identifiers

PMID31386859
OpenAlexW2965665587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.