ArticleCurrent biology : CB2019
Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.iScience · 2025Article
- Leader Cells: Invade and Evade-The Frontline of Cancer Progression.International journal of molecular sciences · 2024Review
- Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.Development (Cambridge, England) · 2024Article
- Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration.Current biology : CB · 2024Article
- RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration.Development (Cambridge, England) · 2024Article
- Pulses of RhoA Signaling Stimulate Actin Polymerization and Flow in Protrusions to Drive Collective Cell Migration.bioRxiv : the preprint server for biology · 2023Article
- Tumour follower cells: A novel driver of leader cells in collective invasion (Review).International journal of oncology · 2023Review
- Who's really in charge: Diverse follower cell behaviors in collective cell migration.Current opinion in cell biology · 2023Review
- Article
- Rear traction forces drive adherent tissue migration in vivo.Nature cell biology · 2022Article
- Collective metastasis: coordinating the multicellular voyage.Clinical & experimental metastasis · 2021Review
- Roles of leader and follower cells in collective cell migration.Molecular biology of the cell · 2021Review
- Review
- Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration.PloS one · 2021Article
- Born to Run? Diverse Modes of Epithelial Migration.Frontiers in cell and developmental biology · 2021Review
- Lamellipodia-like protrusions and focal adhesions contribute to collective cell migration in zebrafish.Developmental biology · 2021Article
- Article
- An adhesion code ensures robust pattern formation during tissue morphogenesis.Science (New York, N.Y.) · 2020Article
- The extracellular matrix in development.Development (Cambridge, England) · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The directed migration of cells sculpts the embryo, contributes to homeostasis in the adult, and, when dysregulated, underlies many diseases [1, 2]. During these processes, cells move singly or as a collective. In both cases, they follow guidance cues, which direct them to their destination [3-6]. In contrast to single cells, collectively migrating cells need to coordinate with their neighbors to move together in the same direction. Recent studies suggest that leader cells in the front sense the guidance cue, relay the directional information to the follower cells in the back, and can pull the follower cells along [7-19]. In this manner, leader cells steer the collective and set the collective's overall speed. However, whether follower cells also participate in steering and speed setting of the collective is largely unclear. Using chimeras, we analyzed the role of leader and follower cells in the collectively migrating zebrafish posterior lateral line primordium. This tissue expresses the chemokine receptor Cxcr4 and is guided by the chemokine Cxcl12a [20-23]. We find that leader and follower cells need to sense the attractant Cxcl12a for efficient migration, are coupled to each other through cadherins, and require coupling to pull Cxcl12a-insensitive cells along. Analysis of cell dynamics in chimeric and protein-depleted primordia shows that Cxcl12a-sensing and cadherin-mediated adhesion contribute jointly to direct migration at both single-cell and tissue levels. These results suggest that all cells in the primordium need to sense the attractant and adhere to each other to coordinate their movements and migrate with robust directionality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.