Trial reportThe American journal of surgical pathology2019
Melorheostosis: A Clinical, Pathologic, and Radiologic Case Series.
Trial report in The American journal of surgical pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- PET/CT Identifies Pubic Melorheostosis with HighMolecular imaging and radionuclide therapy · 2026Article
- A case report and literature review of pediatric multifocal melorheostosis in a unilateral limb.International journal of surgery case reports · 2026Article
- The melorheostosis with severe knee and ankle deformity treated by total knee arthroplasty with V-Y quadricepsplasty: a case report and literature review.BMC musculoskeletal disorders · 2025Review
- Melorheostosis: Clinical, radiological, and histopathological features with a literature review.Physiological reports · 2025Review
- Calvarial melorheostosis: an extremely rare case and diagnostic challenge.Skeletal radiology · 2025Article
- Review
- Melorheostosis: Two Case Reports and Review of Current Literature.Journal of orthopaedic case reports · 2025Article
- Unraveling melorheostosis: insights into clinical features, diagnosis, and treatment.JBMR plus · 2025Review
- Clinical report of metacarpal melorheostosis: a rare disease with "the dripping candle wax" appearance on different imaging modalities.Oxford medical case reports · 2024Article
- VEGF Secretion Drives Bone Formation in Classical MAP2K1+ Melorheostosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Melorheostosis: A Review of the Literature and a Case Report.Medicina (Kaunas, Lithuania) · 2023Review
- Benign incidental do-not-touch bone lesions.The British journal of radiology · 2023Review
- Review
- Bisphosphonate Therapy in the Management of Symptomatic Melorheostosis of Tibia.Journal of orthopaedic case reports · 2021Article
- Cross-Sectional Imaging Useful in Melorheostosis.JBMR plus · 2021Article
- Melorheostosis of the Fossa Intercondylaris Femoris - A Case Report and Review of the Literature.Journal of orthopaedic case reports · 2021Article
- Response to: letter to the editor re: Osteoma-like melorheostosis: a rare type of skeletal dysplasia depicted on FDG PET/CT.Skeletal radiology · 2020Article
- The dripping candle wax sign of melorheostosis.SAGE open medical case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Melorheostosis is a rare sclerosing bone disease characterized by excessive cortical bone deposition that is frequently on the differential diagnosis for bone biopsies. Although the radiologic pattern of "dripping candle wax" is well known, the pathologic findings have been poorly defined. Here, we comprehensively describe the histology of melorheostosis in 15 patients who underwent bone biopsies. Common histologic findings included: dense cortical bone (73.3%), woven bone (60%), and hypervascular features and increased porosity (66.7%). One third of the patients (5/15) also had prominent cement lines. Multiple patients had >1 histologic pattern (ie, dense cortical bone and hypervascularity). Overall, this study suggests that melorheostosis exists with several histologically distinct patterns. When confronted with a case of suspected melorheostosis, the clinical pathologist should use the histologic features common to melorheostotic lesions presented here in conjunction with the patient's clinical presentation and radiographic findings to arrive at a diagnosis. An illustrative case is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.