Evidence map›Paper›PMID 31386628›Full record

ArticleAging2019

Immune system development and age-dependent maintenance in Klotho-hypomorphic mice.

Wandi Sandra Zhu, Lynette Naler, Robert W Maul, Michelle A Sallin, Jyoti Misra Sen

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Wandi Sandra ZhuNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Lynette NalerNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Robert W MaulNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Michelle A SallinNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Jyoti Misra SenNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
National Institutes of Health · USJohns Hopkins University · USNational Institute on Aging · USUniversity of California, San Francisco · US

Funding

T cell development in the thymus and age-dependent thymic involutionZIAAG000768 · NIA · NATIONAL INSTITUTE ON AGING · PI EGAN, JOSEPHINE · 2009 to 2025
$4.0M
6 · The paper itself

Abstract

Circulating Klotho peptide hormone has anti-aging activity and affects tissue maintenance. Hypomorphic mutant Klotho [

Indexed as

AgingAnimalsBone MarrowGlucuronidaseKlotho ProteinsMiceMice, Inbred C57BLMice, Mutant StrainsThymus GlandVitamin DGlucuronidaseKlotho ProteinsVitamin DagingC57BL/6 backgroundimmune cellsklotho hypomorphic allelevitamin D3

Identifiers

PMID31386628
PMCPMC6682518
OpenAlexW2966627393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.