Evidence map›Paper›PMID 31386623›Full record

ArticleeLife2019

A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.

Joo Lee, Caitlin A Taylor, Kristopher M Barnes, Ao Shen, Emerson V Stewart, Allison Chen, Yang K Xiang, Zhirong Bao, Kang Shen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

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  17. Regulation of Gliogenesis byG3 (Bethesda, Md.) · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Joo LeeDepartment of Biochemistry, Stanford University, Stanford, United States.ORCID 0000-0001-5875-6036
Caitlin A TaylorHoward Hughes Medical Institute, Stanford University, Stanford, United States.ORCID 0000-0003-0016-9175
Kristopher M BarnesDevelopmental Biology Program, Sloan-Kettering Institute, New York, United States.
Ao ShenDepartment of Pharmacology, University of California, Davis, Davis, United States.
Emerson V StewartDepartment of Biology, Stanford University, Stanford, United States.
Allison ChenDevelopmental Biology Program, Sloan-Kettering Institute, New York, United States.
Yang K XiangDepartment of Pharmacology, University of California, Davis, Davis, United States.
Zhirong BaoDevelopmental Biology Program, Sloan-Kettering Institute, New York, United States.ORCID 0000-0002-2201-2745
Kang ShenHoward Hughes Medical Institute, Stanford University, Stanford, United States.ORCID 0000-0003-4059-8249
Howard Hughes Medical Institute · USKettering University · USUniversity of California, Davis · USStanford University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
WormGUIDES: A Resource for Global Understanding in Dynamic Embryonic SystemsR24OD016474 · OD · YALE UNIVERSITY · PI BAO, ZHIRONG, COLON-RAMOS, DANIEL A · 2013 to 2020
$6.5M
The Ubiquitin-Proteasome System in Metazoan EmbryogenesisR01GM097576 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAO, ZHIRONG · 2011 to 2020
$3.3M
Mechanisms of synaptic specificity in C. elegansR37NS048392 · NINDS · STANFORD UNIVERSITY · PI SHEN, KANG · 2015 to 2019
$2.0M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM097576NIH HHS R24 OD016474NIH HHS R37 NS048392NIH HHS T32 GM007276
6 · The paper itself

Abstract

Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Here, we show that

Indexed as

Cell DifferentiationGene Expression RegulationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEpithelial CellsNeuronsTrans-ActivatorsTranscription FactorsCaenorhabditis elegans ProteinsTrans-ActivatorsTranscription Factorsztf-11 protein, C elegansC. elegansdevelopmental biologygeneticsgenomicsMuvB complexMyt1neurogenesisneuronal differentiationtranscriptional repressionZTF-11

Identifiers

PMID31386623
PMCPMC6684318
OpenAlexW2965181024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.