ArticlePhysical review letters2019
Error-Speed Correlations in Biopolymer Synthesis.
Article in Physical review letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- Thermodynamic limits in far-from-equilibrium molecular templating networks.Newton ((New York, N.Y.) · 2026Article
- Bridging ribosomal synthesis to cell growth through the lens of kinetics.Biophysical journal · 2023Article
- Nonequilibrium Thermodynamics in Biochemical Systems and Its Application.Entropy (Basel, Switzerland) · 2021Review
- Session 2SDA-Nonequilibrium energetics of biological molecular machines.Biophysical reviews · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. The performance of these enzymes is usually characterized in terms of their average error rate and speed. However, because of thermal fluctuations in these single-molecule processes, both error and speed are inherently stochastic quantities. In this Letter, we study fluctuations of error and speed in biopolymer synthesis and show that they are in general correlated. This means that, under equal conditions, polymers that are synthesized faster due to a fluctuation tend to have either better or worse errors than the average. The error-correction mechanism implemented by the enzyme determines which of the two cases holds. For example, discrimination in the forward reaction rates tends to grant smaller errors to polymers with faster synthesis. The opposite occurs for discrimination in monomer rejection rates. Our results provide an experimentally feasible way to identify error-correction mechanisms by measuring the error-speed correlations.
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