ArticleThe British journal of surgery2019
Nationwide study of appendicitis in children.
Article in The British journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05511194 (Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Post-discharge oral home antibiotic use in complicated pediatric appendicitis: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2026Pooled it
- Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis.Pathogens and global health · 2022Pooled it
- Epidemiological patterns of general surgical emergencies during Hajj pilgrimage: a 10-year retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Routine Biomarkers in Paediatric Appendicitis Stratification: Which Add Diagnostic Value? A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Nutritional Status as a Risk Factor for Appendiceal Perforation in Pediatric Acute Appendicitis: Systematic Review.Children (Basel, Switzerland) · 2026Review
- Serum immunoglobulin A in pediatric appendicitis.Scientific reports · 2026Article
- Minimally Invasive Surgical Techniques in the Treatment of Appendicitis: A Narrative Review.Cureus · 2025Review
- Spatial Accessibility to Emergency Departments and Surgical Treatment for Patients with Acute Appendicitis in South Korea.Yonsei medical journal · 2025Article
- Analysis of Incidence and Risk Factors of Complicated Acute Appendicitis in Children: Evidence From a Tertiary Pediatric Center.International journal of pediatrics · 2025Article
- Childhood appendectomy and subsequent psychiatric illness.PLOS mental health · 2025Article
- Risk Factors for Postoperative Intra-Abdominal Abscess in Pediatric Perforated Appendicitis Following Laparoscopic Appendectomy: A Multicenter Analysis.Children (Basel, Switzerland) · 2024Article
- Management and outcomes of acute appendicitis in children with congenital heart disease.Pediatric surgery international · 2024Review
- Article
- SAME day amBulatory c (SAMBA): a multicenter, prospective, randomized clinical trial protocol.Trials · 2024Article
- Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis.World journal of gastrointestinal surgery · 2024Article
- Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship.Paediatric drugs · 2024Review
- Risk factors for complications after emergency surgery for paediatric appendicitis: a national prospective observational cohort study.Anaesthesia · 2024Observational
- A rare case of cecal foreign body leading to cecal perforation in 12-year-old child: a clinical case report and review of literature.Annals of medicine and surgery (2012) · 2024Article
- Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens-A Retrospective Cohort Study between 2010 and 2019 in The Netherlands.Children (Basel, Switzerland) · 2023Article
- Reasons for Delayed Diagnosis of Pediatric Acute Appendicitis during the COVID-19 Era: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPaediatric surgical care is increasingly being centralized away from low-volume centres, and prehospital delay is considered a risk factor for more complicated appendicitis. The aim of this study was to determine the incidence of paediatric appendicitis in Sweden, and to assess whether distance to the hospital was a risk factor for complicated disease.
methodsA nationwide cohort study of all paediatric appendicitis cases in Sweden, 2001-2014, was undertaken, including incidence of disease in different population strata, with trends over time. The risk of complicated disease was determined by regression methods, with travel time as the primary exposure and individual-level socioeconomic determinants as independent variables.
resultsSome 38 939 children with appendicitis were identified. Of these, 16·8 per cent had complicated disease, and the estimated risk of paediatric appendicitis by age 18 years was 2·5 per cent. Travel time to the treating hospital was not associated with complicated disease (adjusted odds ratio (OR) 1·00 (95 per cent c.i. 0·96 to 1·05) per 30-min increase; P = 0·934). Level of education (P = 0·177) and family income (P = 0·120) were not independently associated with increased risk of complicated disease. Parental unemployment (adjusted OR 1·17, 95 per cent c.i. 1·05 to 1·32; P = 0·006) and having parents born outside Sweden (1 parent born in Sweden: adjusted OR 1·12, 1·01 to 1·25; both parents born outside Sweden: adjusted OR 1·32, 1·18 to 1·47; P < 0·001) were associated with an increased risk of complicated appendicitis.
conclusionEvery sixth child diagnosed with appendicitis in Sweden has a more complicated course of disease. Geographical distance to the surgical facility was not a risk factor for complicated appendicitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.