Evidence map›Paper›PMID 31386148›Full record

ArticleAdvances in nutrition (Bethesda, Md.)2020

Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches.

Padma Maruvada, Johanna W Lampe, David S Wishart, Dinesh Barupal, Deirdra N Chester, Dylan Dodd, Yannick Djoumbou-Feunang, Pieter C Dorrestein, Lars O Dragsted, John Draper and 26 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in nutrition (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Padma MaruvadaNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Johanna W LampePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
David S WishartDepartments of Biological Sciences and Computing Science, University of Alberta, Edmonton, Alberta, Canada.
Dinesh BarupalWest Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, Davis, CA, USA.
Deirdra N ChesterDivision of Nutrition, Institute of Food Safety and Nutrition at the National Institute of Food and Agriculture, USDA, Washington, DC, USA.
Dylan DoddDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Yannick Djoumbou-FeunangDepartments of Biological Sciences and Computing Science, University of Alberta, Edmonton, Alberta, Canada.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Lars O DragstedDepartment of Nutrition, Exercise, and Sports, Section of Preventive and Clinical Nutrition, University of Copenhagen, Copenhagen, Denmark.
John DraperInstitute of Biological Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, Ceredigion, United Kingdom.
Linda C DuffyNational Institutes of Health, National Center for Complementary and Integrative Health, Bethesda, MD, USA.
Johanna T DwyerNational Institutes of Health, Office of Dietary Supplements, Bethesda, MD, USA.
Nancy J EmenakerNational Institutes of Health, National Cancer Institute, Rockville, MD, USA.
Oliver FiehnWest Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, Davis, CA, USA.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Frank B HuDepartments of Nutrition; Epidemiology and Statistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
Robert W KarpNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
David M KlurfeldDepartment of Nutrition, Food Safety/Quality, USDA-Agricultural Research Service, Beltsville, MD, USA.
Maren R LaughlinNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
A Roger LittleNational Institutes of Health, National Institute on Drug Abuse, Bethesda, MD, USA.
Christopher J LynchNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Steven C MooreNational Institutes of Health, National Cancer Institute, Rockville, MD, USA.
Holly L NicastroNational Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Diane M O'BrienInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
José M OrdovásNutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Stavroula K OsganianNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Mary PlaydonDepartment of Nutrition and Integrative Physiology, University of Utah and Division of Cancer Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Ross PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daniel RafteryPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nichole ReisdorphUniversity of Colorado Anschutz Medical Campus, Denver, CO, USA.
Helen M RocheNutrigenomics Research Group, School of Public Health, Physiotherapy and Sports Science, UCD Institute of Food and Health, Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.
Sharon A RossNational Institutes of Health, National Cancer Institute, Rockville, MD, USA.
Shengmin SangLaboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, North Carolina Research Campus, Nutrition Research Building, Kannapolis, NC, USA.
Augustin ScalbertInternational Agency for Research on Cancer, Nutrition and Metabolism Section, Biomarkers Group, Lyon, France.
Pothur R SrinivasNational Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Steven H ZeiselNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN TORRIANI · 1994 to 2026
$31.6M
Physical Activity, Energy Balance, and CancerZIACP010197 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$17.5M
Molecular Stable Isotope Profiles of Dietary ExposureR01DK109946 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI O'BRIEN, DIANE MARIE · 2016 to 2019
$1.7M
Modulation of gut bacteria-derived host metabolitesK08DK110335 · NIDDK · STANFORD UNIVERSITY · PI DODD, DYLAN · 2018 to 2021
$573k
Medical Research Council MR/J010308/1NIDDK NIH HHS K08 DK110335NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK109946World Health Organization 001
6 · The paper itself

Abstract

While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research.

Indexed as

DietBiomarkersFoodGenomicsHumansMetabolomicsMetagenomicsNutritional Physiological PhenomenaNutritional SciencesNutritional StatusReproducibility of ResultsBiomarkersdietdietary biomarkersdietary intervention studiesmetabolomicsnutrition

Identifiers

PMID31386148
PMCPMC7442414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.