ArticleNeuro-oncology practice2015
Cognitive function, depression, fatigue and quality of life among long-term survivors of head and neck cancer.
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Article in Neuro-oncology practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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Who cites it
9 citing papers in PubMed.
- Timeline of cognitive impairments after radiotherapy for head and neck cancer: A review.Clinical and translational radiation oncology · 2025Review
- "Why am I still suffering?": Experience of long-term fatigue and neurocognitive changes in oropharyngeal cancer survivors following (chemo)radiotherapy.Technical innovations & patient support in radiation oncology · 2024Article
- Article
- Body image concerns in long-term head and neck cancer survivors: prevalence and role of clinical factors and patient-reported late effects.Journal of cancer survivorship : research and practice · 2023Article
- Long-term cognitive, psychosocial, and neurovascular complications of unilateral head and neck irradiation in young to middle-aged adults.BMC cancer · 2022Article
- "I would have told you about being forgetful, but I forgot": the experience of cognitive changes and communicative participation after head and neck cancer.Disability and rehabilitation · 2020Article
- Quality improvement of neuro-oncology services: integrating the routine collection of patient-reported, health-related quality-of-life measures.Neuro-oncology practice · 2019Article
- Assessment of Neurocognitive Impairment and Speech Functioning Before Head and Neck Cancer Treatment.JAMA otolaryngology-- head & neck surgery · 2019Article
- Baseline Cognition Assessment Among Patients With Oropharyngeal Cancer Using PROMIS and NIH Toolbox.JAMA otolaryngology-- head & neck surgery · 2018Article
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Authors and funding
11 authors.
Joyce WilbersDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Arnoud C KappelleDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Laura VersteegDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Anil M TuladharDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Stefan C A SteensDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Frederick J A MeijerDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Willem BoogerdDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Lucille D DorresteijnDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Johannes H KaandersDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Roy P C KesselsDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Ewoud J van DijkDepartment of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen PO Box 9101, 6500 HB Nijmegen, the Netherlands (J.W., A.C.K., A.M.T., E.J.v.D.); Department of Medical Psychology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HE, the Netherlands (L.V., R.P.C.K.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands (S.C.A.S., F.J.A.M.); Department of Neurology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, the Netherlands (W.B.); Department of Neurology, Medisch Spectrum Twente, PO Box 50000, 7500 KA Enschede, the Netherlands (L.D.D.); Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (J.H.K.).
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term cancer treatment complications become more prevalent as survival improves. Little is known about the psychological complications in long-term survivors of head and neck cancer (HNC). We investigated cognitive functioning and its relation with depression, fatigue, cognitive complaints, and brain lesions on MRI.
methodsThis study is part of a multicentre, prospective cohort study of 65 patients treated for HNC. A comprehensive neuropsychological assessment was combined with validated questionnaires on subjective memory complaints, depression, and fatigue after a median of 7 years follow-up. Results were compared with age- and education-adjusted normative data. Further, we evaluated cerebral white matter hyperintensities (WMH), brain volume, and infarctions on MRI.
resultsHNC patients had worse cognitive performance in two of the five assessed cognitive domains: episodic memory (
conclusionLong-term HNC survivors showed worse cognitive functioning 7 years after treatment. Cognitive function was associated with subjective complaints and fatigue, but not with depressive symptoms. Cerebral infarctions on MRI were correlated with cognitive function, whereas WMH, and brain volume were not.
Indexed as
cognitiondepressionfatiguehead and neck cancerwhite matter hyperintensities
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