Evidence map›Paper›PMID 31386041›Full record

ReviewNeuro-oncology practice2019

Molecular tools for the pathologic diagnosis of central nervous system tumors.

Loudy P Priesterbach-Ackley, Pieter Wesseling, Tom J Snijders, Filip Y F L de Vos, Wendy W J de Leng

Abstract readReview
In one paragraph

Review in Neuro-oncology practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Molecular pathology of tumors of the central nervous system.Annals of oncology : official journal of the European Society for Medical Oncology · 2019
    Review
  9. Article
  10. Determination ofIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Loudy P Priesterbach-AckleyDepartment of Pathology, University Medical Center Utrecht, The Netherlands.ORCID 0000-0002-3480-634X
Pieter WesselingDepartment of Pathology, Princess Máxima Center for Pediatric Oncology and University Medical Center Utrecht, The Netherlands.
Tom J SnijdersDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.ORCID 0000-0003-0857-081X
Filip Y F L de VosDepartment of Medical Oncology, University Medical Center Utrecht, The Netherlands.
Wendy W J de LengDepartment of Pathology, University Medical Center Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular diagnostics currently has a crucial role in neuro-oncological patient care. (Epi)genetic assays testing for point mutations, copy number variations, gene fusions, translocations, and methylation status are of main diagnostic interest in neuro-oncology. Multiple assays have been developed for this purpose, ranging from single gene tests to high-throughput, integrated techniques enabling detection of multiple genetic aberrations in a single workflow. This review describes the nature of the simpler and more complex assays for molecular diagnostics of tumors of the central nervous system and briefly discusses their strengths and weaknesses.

Indexed as

diagnosisepigeneticsgenetic alterationsmolecular pathologyneuro-oncology

Identifiers

PMID31386041
PMCPMC6656323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.