Evidence map›Paper›PMID 31386035›Full record

ReviewNeuro-oncology practice2018

Case-based review: ependymomas in adults.

David Cachia, Derek R Johnson, Timothy J Kaufmann, Stephen Lowe, Samuel Andersen, Adriana Olar, Samuel Lewis Cooper, Bruce M Frankel, Mark R Gilbert

Abstract readReview
In one paragraph

Review in Neuro-oncology practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David CachiaDepartment of Neuro-surgery, Medical University of South Carolina, Charleston, USA.
Derek R JohnsonDepartment of Neurology and Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Timothy J KaufmannDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Stephen LoweDepartment of Neuro-surgery, Medical University of South Carolina, Charleston, USA.
Samuel AndersenDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, USA.
Adriana OlarDepartment of Neuro-surgery, Medical University of South Carolina, Charleston, USA.
Samuel Lewis CooperDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, USA.
Bruce M FrankelDepartment of Neuro-surgery, Medical University of South Carolina, Charleston, USA.
Mark R GilbertDepartment of Neuro-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ependymomas are rare primary central nervous system (CNS) tumors in adults. They occur most commonly in the spinal cord, and have classically been graded histologically into World Health Organization (WHO) grades I, II, or III based on the level of anaplasia. Recent data are showing that genetic heterogeneity occurs within the same histological subgroup and that ependymomas arising from different CNS locations have different molecular signatures. This has renewed interest in developing targeting therapies based on molecular profiles especially given the variable outcomes with radiation and the poor results with cytotoxic agents. In this paper, we present the case of a 46-year-old woman with a classic presentation of spinal cord ependymoma and discuss the current histopathological and molecular classification for ependymomas as well as current guidelines for patient management.

Indexed as

adultschemotherapyependymomaradiationsurgery

Identifiers

PMID31386035
PMCPMC6656336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.