ReviewNeuro-oncology practice2017
Optic neuropathy in the context of leukemia or lymphoma: diagnostic approach to a neuro-oncologic emergency.
Review in Neuro-oncology practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- B-Cell Acute Lymphoblastic Leukemia Relapse Presenting as Choroidal Infiltration Confirmed by Choroidal Biopsy Along with Ipsilateral Optic Nerve Involvement.Neuro-ophthalmology (Aeolus Press) · 2026Article
- Clinical characteristics of leukemic optic nerve infiltration in pediatric acute lymphoblastic leukemia: 3 cases and a literature review.Frontiers in medicine · 2026Article
- Don't lose sight: rare extramedullary involvement of myeloid/lymphoid neoplasm withHaematologica · 2025Article
- Leukaemic Optic Neuropathy in a Patient with Treated Acute Lymphoblastic Leukaemia: Optical Coherence Tomography as an Aid to Diagnosis.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Optic Disc Swelling in Cancer Patients: Etiology and Implications.Journal of clinical medicine · 2023Article
- Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?Antioxidants (Basel, Switzerland) · 2023Review
- Acute lymphoblastic leukemia relapse presenting with optic nerve infiltration.SAGE open medical case reports · 2023Article
- Article
- Hypocellular Philadelphia chromosome-positive mixed-phenotype acute leukemia successfully treated with dasatinib: A case report.Molecular and clinical oncology · 2022Article
- Radiological Features of Bilateral Sequential Leukaemic Optic Nerve Infiltration: A Case Report.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia.Neuro-ophthalmology (Aeolus Press) · 2022Article
- A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss.Case reports in oncological medicine · 2020Article
- Optic neuropathy as the first sign of central nervous system relapse in acute myeloid leukaemia: MRI findings and its diagnostic challenge.BMJ case reports · 2019Article
- Optic disc and peripapillary tumors.Taiwan journal of ophthalmologyReview
- Evaluation of visual evoked potential in chronic myeloid leukemias.Oman journal of ophthalmologyArticle
- Vitreous cytology as the only diagnostic evidence of central nervous system involvement in a patient with isolated leukemic infiltrative optic neuropathy.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptic neuropathy in the context of leukemia or lymphoma has a broad differential diagnosis, including infiltration, infection, inflammation, compression, and medication effects. Confirming the underlying etiology in a timely manner is crucial as, while infiltration carries a poor prognosis, treatment modalities can have serious consequences themselves.
methodsA review of the literature was conducted for cases of isolated optic neuropathy in the context of leukemia or lymphoma, in which the underlying etiology remained unclear following initial clinical examination and neuroimaging. Clinical, radiological, and pathological characteristics of the cases are summarized.
resultsNinety-two cases meeting inclusion criteria were identified. Leukemic or lymphomatous infiltration was the presumed diagnosis in 72% of the reports, indicating this is the most likely etiology in such cases. The remaining reports were attributed to inflammation, infection, or drug toxicity. For illustrative purposes, the previously unpublished case of an 11-year-old girl with remitted T lymphoblastic lymphoma is presented. She suffered recurrence in the form of isolated left optic nerve infiltration that required transconjunctival biopsy to confirm diagnosis.
conclusionsOptic nerve infiltration by leukemia or lymphoma requires both diagnostic certainty and urgent management. Recommendations are made for a step-wise, yet rapid investigative approach that may ultimately require biopsy of the optic nerve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.