Evidence map›Paper›PMID 31386000›Full record

ArticleNeuro-oncology practice2019

Incidence and prognostic factors of ataxia in children with posterior fossa tumors.

Helen Hartley, Barry Pizer, Steven Lane, Christine Sneade, Rebecca Williams, Conor Mallucci, Lisa Bunn, Ram Kumar

Open access · bronzeAbstract read
In one paragraph

Article in Neuro-oncology practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Proceedings of the first global meeting of the Posterior Fossa Society: state of the art in cerebellar mutism syndrome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  4. Article
  5. Article
  6. Ataxia and mobility in children following surgical resection of posterior fossa tumour: A longitudinal cohort study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  7. Article
  8. Post-operative cerebellar mutism syndrome: rehabilitation issues.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Helen HartleyPhysiotherapy Department, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.ORCID 0000-0001-5645-0666
Barry PizerOncology Department, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Steven LaneDepartment of Biostatistics, University of Liverpool, UK.
Christine SneadePhysiotherapy Department, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Rebecca WilliamsPhysiotherapy Department, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Conor MallucciDepartment of Neurosurgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Lisa BunnSchool of Health Professions, University of Plymouth, UK.
Ram KumarDepartment of Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Alder Hey Children's NHS Foundation Trust · GBUniversity of Liverpool · GBUniversity of Plymouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is minimal literature specific to motor outcomes in children with posterior fossa tumors (PFTs) despite ataxia being a significant problem in this group. This study aims to report children's physical outcomes following management of PFT and determine which factors affect severity of ataxia and functional limitations.

methodsForty-two children aged between 5 and 17 and between 1 and 4 years following surgery for PFT were assessed using the Scale for the Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and the mobility Pediatric Evaluation of Disability Inventory (PEDI) subscale to determine prevalence and severity of ataxia and a measure of physical function. Analysis was undertaken comparing impact of tumor location, tumor histology, adjuvant treatment, age at diagnosis, presence of preoperative ataxia, and presence of cerebellar mutism syndrome (CMS) on ataxia and physical function scores.

resultsSeventy-one percent of children demonstrated a SARA and BARS score greater than 2. A total of 48% of children had a PEDI-m score greater than 90. There was no correlation between age at diagnosis or preoperative ataxia and assessment scores. There was a significant difference in SARA/BARS and PEDI-mobility scores depending on tumor histology, tumor location, and presence of CMS.

conclusionsA high proportion of children (>1 year) following surgery for PFT continue to present with ataxia. Higher ataxia and lower physical function scores were demonstrated in children with medulloblastoma and midline tumors and those diagnosed with CMS. The high prevalence of ataxia demonstrates the need for further research regarding rehabilitation management in this population.

Indexed as

ataxiapediatricsposterior fossa tumor

Identifiers

PMID31386000
PMCPMC6656303
OpenAlexW2884314866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.