Evidence map›Paper›PMID 31385407›Full record

ArticleCancer science2019

Supplementary granulocyte macrophage colony-stimulating factor to chemotherapy and programmed death-ligand 1 blockade decreases local recurrence after surgery in bladder cancer.

Makito Miyake, Shunta Hori, Sayuri Ohnishi, Michihiro Toritsuka, Tomomi Fujii, Takuto Shimizu, Takuya Owari, Yosuke Morizawa, Daisuke Gotoh, Yoshitaka Itami and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Makito MiyakeDepartment of Urology, Nara Medical University, Nara, Japan.ORCID https://orcid.org/0000-0001-9503-7356
Shunta HoriDepartment of Urology, Nara Medical University, Nara, Japan.
Sayuri OhnishiDepartment of Urology, Nara Medical University, Nara, Japan.
Michihiro ToritsukaDepartment of Psychiatry, Nara Medical University, Nara, Japan.
Tomomi FujiiDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.ORCID https://orcid.org/0000-0002-7207-4127
Takuto ShimizuDepartment of Urology, Nara Medical University, Nara, Japan.
Takuya OwariDepartment of Urology, Nara Medical University, Nara, Japan.
Yosuke MorizawaDepartment of Urology, Nara Medical University, Nara, Japan.
Daisuke GotohDepartment of Urology, Nara Medical University, Nara, Japan.
Yoshitaka ItamiDepartment of Urology, Nara Medical University, Nara, Japan.
Yasushi NakaiDepartment of Urology, Nara Medical University, Nara, Japan.
Satoshi AnaiDepartment of Urology, Nara Medical University, Nara, Japan.
Kazumasa TorimotoDepartment of Urology, Nara Medical University, Nara, Japan.
Nobumichi TanakaDepartment of Urology, Nara Medical University, Nara, Japan.
Kiyohide FujimotoDepartment of Urology, Nara Medical University, Nara, Japan.
Nara Medical University · JP

Funding

JSPS KAKENHI 16K20159JSPS KAKENHI 26861290Nara Medical University Grant-in-Aid for Collaborative Research Projects
6 · The paper itself

Abstract

Despite advances and refinements in surgery and perioperative chemotherapy, there are still unmet medical needs with respect to radical cystectomy for muscle-invasive bladder cancer (MIBC). We investigated the potential benefit of supplementary granulocyte macrophage colony-stimulating factor (GM-CSF) to chemoimmunotherapy with programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis blockade and standard neoadjuvant chemotherapy in bladder cancer. We inoculated 2 × 10

Indexed as

AnimalsAntineoplastic Agents, ImmunologicalB7-H1 AntigenCell Line, TumorCisplatinCombined Modality TherapyCystectomyDeoxycytidineEpithelial-Mesenchymal TransitionGemcitabineGranulocyte-Macrophage Colony-Stimulating FactorHumansMargins of ExcisionMiceNeoadjuvant TherapyNeoplasm Recurrence, LocalAntineoplastic Agents, ImmunologicalB7-H1 AntigenCD274 protein, humanCisplatinDeoxycytidineGemcitabineGranulocyte-Macrophage Colony-Stimulating Factorbladder neoplasmcolony-stimulating factorlocal recurrenceneoadjuvant chemoimmunotherapyradical cystectomy

Identifiers

PMID31385407
PMCPMC6778624
OpenAlexW2966078896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.