Evidence map›Paper›PMID 31385264›Full record

ArticleRheumatology and therapy2019

Patient Perceptions of Unmet Medical Need in Rheumatoid Arthritis: A Cross-Sectional Survey in the USA.

Christine Radawski, Mark C Genovese, Brett Hauber, W Benjamin Nowell, Kelly Hollis, Carol L Gaich, Amy M DeLozier, Kelly Gavigan, Maria Reynolds, Anabela Cardoso and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Rheumatology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245732 (STeroid Options for RA Management), which is not on this map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07245732 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

STeroid Options for RA Management (STORM-RA): Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares: A Pragmatic Randomized Clinical Trial

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2026 to 2029Enrolled220ConditionsRheumatoid Arthritis (RA)ArmsGlucocorticoid (GC)
3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christine RadawskiEli Lilly and Company, Indianapolis, IN, USA. c.radawski@lilly.com.
Mark C GenoveseStanford University, Palo Alto, CA, USA.
Brett HauberRTI Health Solutions, Research Triangle Park, NC, USA.
W Benjamin NowellGlobal Healthy Living Foundation, Upper Nyack, NY, USA.
Kelly HollisRTI Health Solutions, Research Triangle Park, NC, USA.
Carol L GaichEli Lilly and Company, Indianapolis, IN, USA.
Amy M DeLozierEli Lilly and Company, Indianapolis, IN, USA.
Kelly GaviganGlobal Healthy Living Foundation, Upper Nyack, NY, USA.
Maria ReynoldsRTI Health Solutions, Research Triangle Park, NC, USA.
Anabela CardosoEli Lilly and Company, Indianapolis, IN, USA.
Jeffrey R CurtisUniversity of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Patient-Centered Outcomes Research Institute PPRN-1306-04811
6 · The paper itself

Abstract

introductionMany rheumatoid arthritis (RA) patients do not achieve their treatment goals and experience symptoms that affect psychosocial outcomes and daily activities. This study aimed to identify and quantify the unmet needs perceived by US patients with RA currently taking a disease-modifying antirheumatic drug (DMARD).

methodsA cross-sectional, web-based survey was conducted with RA patients recruited through CreakyJoints, an online patient support community, and ArthritisPower

resultsOf 415 patients screened, 258 (62%) were eligible and completed the survey; 87% were women, and 87% white, with mean (SD) age of 54.5 (11.4) years. A total of 232 patients (90%) had current or past biologic DMARD (bDMARD) use, with 67% currently on a bDMARD, 65% on ≥ 1 conventional synthetic DMARD, and 40% on methotrexate. Forty-three percent of patients reported daily/almost daily use of prescription pain medications, and 44% reported a current flare. Mean (SD) TSQM scores were 59 [20] for effectiveness, 59 [26] for side effects, 72 [18] for convenience, and 65 [21] for global satisfaction. The mean (SD) RAID overall score was 5.1 (2.0) on a 0-10 scale. Only 26% (67 patients) were satisfied with their RA treatment. Patients not satisfied with treatment reported higher RAID scores overall and by domain, and approximately half reported a current flare.

conclusionsResults from this real-world survey suggest that three-fourths of RA patients are not satisfied with treatments, which include bDMARDs. Patients continued to experience bothersome symptoms that impacted their daily activities and life. There remains a need for improved disease management among currently treated RA patients.

fundingEli Lilly and Company (Indianapolis, IN, USA).

Indexed as

Patient-reported outcomesRheumatoid arthritisSatisfactionSurvey researchUnmet need

Identifiers

PMID31385264
PMCPMC6702617

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.