ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020
Orthostatic heart rate does not predict symptomatic burden in pediatric patients with chronic orthostatic intolerance.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Association between symptoms of pediatric postural orthostatic tachycardia syndrome and joint hypermobility syndromes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance.The Journal of pediatrics · 2026Article
- Patient Characteristics of a Telemedicine Clinic for Pediatric and Young Adult Postural Orthostatic Tachycardia Syndrome.Journal of clinical medicine · 2026Article
- Postural orthostatic tachycardia syndrome in adolescents with ME/CFS - a case control study.Frontiers in pediatrics · 2026Article
- Long-Term Postural Orthostatic Tachycardia Syndrome Outcomes Survey: Educational, Economic, and Social Impact.Journal of the American Heart Association · 2025Article
- Orthostatic Intolerance in Children With Long COVID Utilizing a 10-Minute Passive Standing Test.Clinical pediatrics · 2025Article
- Outcomes of Pediatric Patients with Excessive Postural Tachycardia After Attending an Intensive Interdisciplinary Pain Program: A Pilot Study.Children (Basel, Switzerland) · 2025Article
- Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction.Scientific reports · 2025Article
- Association of postural orthostatic tachycardia syndrome, hypermobility spectrum disorders, and mast cell activation syndrome in young patients; prevalence, overlap and response to therapy depends on the definition.Frontiers in neurology · 2025Article
- Hyperventilation during rest and exercise in orthostatic intolerance and Spiky-Leaky Syndrome.Frontiers in neurology · 2025Article
- The Long-Term Postural Orthostatic Tachycardia Syndrome Outcomes Survey-Gynecologic Findings: A Cross-Sectional Survey in Young Women.Obstetrics and gynecology international · 2025Article
- Long-Term POTS Outcomes Survey: Diagnosis, Therapy, and Clinical Outcomes.Journal of the American Heart Association · 2024Article
- How should we measure the "POT" of POTS, and how much does it matter?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Poor health-related quality of life in postural orthostatic tachycardia syndrome in comparison with a sex- and age-matched normative population.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways.Scientific reports · 2022Article
- Cardiovascular Autonomic Regulation, ETCOApplied psychophysiology and biofeedback · 2022Article
- Dysautonomia in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders is associated with exercise intolerance and cardiac atrophy.American journal of medical genetics. Part A · 2021Article
- Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2.Autonomic neuroscience : basic & clinical · 2021Article
- "Dysautonomia": a plea for precision.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Diagnostic Value of Diurnal Variability of Orthostatic Heart Rate Increment in Children and Adolescents With POTS.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePostural orthostatic tachycardia syndrome (POTS) in adults is defined as symptoms of chronic orthostatic intolerance (COI) and autonomic dysfunction (AD) with heart rate (HR) increase of 30 beats per minute (bpm), or HR > 120 bpm, during prolonged upright position. However, in adolescents, POTS is defined as symptoms of OI and AD with HR increase of ≥ 40 bpm, based on tilt table data. We assessed frequency of COI symptoms in pediatric patients versus HR criteria on prolonged standing to evaluate using criteria of increased HR of 30-39 bpm versus ≥ 40 bpm in our POTS Program.
methodsPatients with COI with symptoms for > 3 months plus HR increase of ≥ 30 bpm on 10 min stand aged ≤ 18 years at diagnosis were included. Patients were divided into two groups: those with HR increase of 30-39 bpm, and those with HR increase of ≥ 40 bpm or upright HR of > 120 bpm. A total of 28 symptoms described prior to diagnosis were evaluated using chi-square testing to assess for significant differences.
resultsOnly insomnia was found to be significantly different between the two groups. The other 27 symptoms showed no significant difference as a function of HR.
conclusionThere are minimal statistically significant differences and no clinical differences between patients as a function of HR increase during standing. Thus, a 40-bpm threshold for adolescents on standing test may be too high, or a specific HR criteria threshold is neither predictive nor definitive in diagnosing POTS.
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