ArticleJournal of neural transmission (Vienna, Austria : 1996)2019
Motor and non-motor function predictors of mortality in Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- All-Cause and Cause-Specific Mortality in Parkinson's Disease: A Meta-Analysis.Neuroepidemiology · 2026Pooled it
- Subjective cognitive complaints in cognitively unimpaired Parkinson's disease: Associations with affective burden, motor severity, and awareness-related processes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Comparative study of nonmotor symptoms in progressive supranuclear palsy and Parkinson's disease.BMC neurology · 2025Article
- Risk for Mortality in High versus Low Antiparkinsonian Therapy Dose During the First Year of Parkinson's Disease: A Real-World Study.Advances in therapy · 2024Article
- Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Neurological update: non-motor symptoms in atypical parkinsonian syndromes.Journal of neurology · 2023Article
- A Pilot Study of the Effect of a Non-Contact Boxing Exercise Intervention on Respiratory Pressure and Phonation Aerodynamics in People with Parkinson's Disease.Journal of clinical medicine · 2023Article
- Assessing the risks of treatment in Parkinson disease psychosis: An in-depth analysis.PloS one · 2023Article
- Association of Depression With Early Occurrence of Postural Instability in Parkinson's Disease.Journal of movement disorders · 2023Article
- Emerging role of psychosis in Parkinson's disease: From clinical relevance to molecular mechanisms.World journal of psychiatry · 2022Review
- Cerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Mild cognitive impairment in patients with Parkinson's disease: An updated mini-review and future outlook.Frontiers in aging neuroscience · 2022Review
- Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis.Frontiers in neurology · 2022Article
- Increased Mortality in Young-Onset Parkinson's Disease.Journal of movement disorders · 2021Article
- Prevalence of Non-Motor Symptoms and Non-Motor Fluctuations in Parkinson's Disease Using the MDS-NMS.Movement disorders clinical practice · 2021Article
- The impact of SARS-COV2 infection on people in residential care with Parkinson Disease or parkinsonisms: Clinical case series study.PloS one · 2021Observational
- COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson's Disease Patient Care.Journal of movement disorders · 2020Article
- Consensus-Based Recommendations for Advance Directives of People with Parkinson's Disease in Regard to Typical Complications by German Movement Disorder Specialists.Journal of clinical medicine · 2020Article
- Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia.Medicine internationalArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doubts persist regarding the influence of Parkinson's disease (PD) on mortality. Our objective was to assess mortality rates in a prospectively followed cohort of PD patients and the impact of motor and non-motor symptoms in survival. 130 consecutive PD patients were followed during a 4-year period or until death. Baseline assessment included motor function (UPDRSIII, Hoehn and Yahr-HY), incapacity (Schwab and England-S&E, UPDRS II), Health-Related quality of life (EuroQol), non-motor symptoms (Non-Motor Symptom Scale-NMSS, MoCA, REM sleep behavior disorder symptoms questionnaire) and comorbidity burden (Charlson Comorbidity Index-CCI). These were used as predictor variables. Standardized mortality rates (SMR) were calculated, comparing with the general population. The association between mortality and predictors was tested with univariate and multivariate Cox proportional hazard regression models. Overall and gender-related SMRs were similar to the general population. SMR for pneumonia was five times higher than in the general population. Age, disease duration, CCI, EuroQol, dementia, MoCA, S&E, NMSS Hallucinations, HY, and PIGD motor phenotype were significantly associated with mortality. Adjusting for age, gender and disease duration, S&E remained significantly associated with mortality. In multivariate logistic regression analysis, death was significantly associated with disease duration, CCI and NMSS-mood/cognition scores. PD was not associated with an excess of mortality, but conferred a higher probability of dying from pneumonia. Comorbidity was a major determinant, but disease duration, baseline incapacity, cognition, psychosis, mood complaints and HRQL also contributed significantly to mortality.
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Registered trials
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