ArticleVirchows Archiv : an international journal of pathology2020
Sarcoma with MGA-NUTM1 fusion in the lung: an emerging entity.
Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Expanding the spectrum of non-canonical NUT carcinoma: clinicopathological and molecular characterization ofFrontiers in oncology · 2026Article
- Case Report: NUTM1-rearranged lung sarcoma: a rare case imaged with dynamic and staticFrontiers in oncology · 2025Article
- Nuclear protein in testis carcinoma of the lung.Translational oncology · 2023Review
- Unusual lung tumors-from morphology to genetics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- MUC4 is expressed in alveolar rhabdomyosarcoma.Histopathology · 2021Article
- Update on genetically defined lung neoplasms: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumors.Virchows Archiv : an international journal of pathology · 2021Review
- A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors.Laboratory investigation; a journal of technical methods and pathology · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We here document a sarcoma with a recently reported MGA-NUTM1 fusion. A 49-year-old man presented with a nodule in the right lung, which grew to a giant mass in 5 years. The tumor showed uniform oval to spindle cell proliferation in a hypervascular stroma, associated with focal myxoid change and peculiar collagen deposition resembling an osteoid. The tumor showed an undifferentiated phenotype, including negativity for cytokeratin, although it was immunoreactive to BCOR and MUC4, and was initially suspected as BCOR-associated sarcoma. After complete resection, the tumor recurred in the mediastinal lymph node, and the patient died of the disease. RNA sequencing detected MGA (exon 22)-NUTM1 (exon 3), which was confirmed by reverse transcriptase-polymerase chain reaction, Sanger sequencing, fluorescence in situ hybridization, and NUT immunohistochemistry. Clinicopathological features of the present case were similar to some of the reported cases of MGA-NUTM1 sarcomas, suggesting the emergence of a distinct tumor subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.