Evidence map›Paper›PMID 31384930›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2019

Monitoring of cerebral oximetry in patients with postural orthostatic tachycardia syndrome.

Isabella Kharraziha, Hannes Holm, Erasmus Bachus, Olle Melander, Richard Sutton, Artur Fedorowski, Viktor Hamrefors

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Hemodynamic and cerebral oxygenation predictors of visual darkening in pediatric POTS: a cross-sectional study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Cerebral Blood Flow in Orthostatic Intolerance.Journal of the American Heart Association · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Isabella KharrazihaDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Hannes HolmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Erasmus BachusDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Richard SuttonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Artur FedorowskiDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Viktor HamreforsDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPostural orthostatic tachycardia syndrome (POTS) is a disorder of unknown aetiology characterized by orthostatic intolerance and tachycardia with diverse other symptoms, including neurocognitive deficits. Cerebral oximetry non-invasively measures cerebral tissue saturation (SctO2) and has been shown to be informative in syncope evaluation. We aimed to assess SctO2 in POTS patients and those with normal response to orthostatic provocation, relative to haemodynamic parameters and symptoms. METHODS AND

resultsThirty-four patients with POTS (29.1 ± 9.5 years; 26 females) and 34 age-/sex-matched controls with normal head-up tilt tests (HUTs) were included. SctO2 at rest and during HUT were compared between POTS and controls. The relation between SctO2, systolic blood pressure (SBP), and heart rate (HR) during HUT was linearly assessed. SctO2 values were related to dizziness or syncope during HUT. The minimum SctO2-value during HUT was lower (65.4 ± 5.6 vs. 68.2 ± 4.2%, P = 0.023) and changes in SctO2 from supine to minimum HUT value were more pronounced in POTS patients (-5.7 ± 2.9% vs. -4.3 ± 2.1%, P = 0.028). Decrease in SBP from supine to minimum HUT value (P = 0.004) and increase in HR from supine to HUT value at 3 min (P = 0.022) correlated with more pronounced SctO2 decrease in POTS but not controls. SctO2 did not predict syncope or dizziness during HUT.

conclusionPostural orthostatic tachycardia syndrome patients have lower cerebral tissue saturation during orthostatic provocation compared with those subjects having normal haemodynamic response to tilt. Orthostatic decrease in cerebral saturation only weakly correlates with HR increase and does not predict vasovagal reflex in POTS. Other hitherto unknown factors may affect cerebral tissue saturation in POTS.

Indexed as

AdultBlood PressureCerebrovascular CirculationFemaleFollow-Up StudiesHeart RateHumansMaleMonitoring, PhysiologicOximetryPostural Orthostatic Tachycardia SyndromeRetrospective StudiesTilt-Table TestCerebral oximetryHaemodynamic monitoringHead-up tiltOrthostatic intolerancePostural orthostatic tachycardia syndrome

Identifiers

PMID31384930
PMCPMC6877984
OpenAlexW2964612457

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.