Evidence map›Paper›PMID 31384641›Full record

ArticleData in brief2019

Caloric vestibular stimulation for the management of motor and non-motor symptoms in parkinson's disease: Intention-to-treat data.

David Wilkinson, Aleksandra Podlewska, Sarah E Banducci, Tracy Pellat-Higgins, Martin Slade, Mayur Bodani, Mohamed Sakel, Lanty Smith, Peter LeWitt, Kristen Ade

Abstract read
In one paragraph

Article in Data in brief, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David WilkinsonSchool of Psychology, University of Kent, Canterbury, UK.
Aleksandra PodlewskaSchool of Psychology, University of Kent, Canterbury, UK.
Sarah E BanducciScion NeuroStim, LLC, Durham, NC, USA.
Tracy Pellat-HigginsCentre for Health Services Studies, University of Kent, Canterbury, UK.
Martin SladeYale University, School of Public Health, New Haven, CT 06510, USA.
Mayur BodaniNeuropsychiatry Service, Kent & Medway NHS and Social Care Partnership Trust, UK.
Mohamed SakelEast Kent Neuro-Rehabilitation Service, East Kent Hospitals University NHS Foundation Trust, Canterbury, UK.
Lanty SmithScion NeuroStim, LLC, Durham, NC, USA.
Peter LeWittParkinson's Disease & Movement Disorders Program, Henry Ford Hospital, Wayne State University School of Medicine, West Bloomfield, MI 48322, USA.
Kristen AdeScion NeuroStim, LLC, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report provides data related to the safety and effectiveness of repeated time-varying caloric vestibular stimulation (CVS) as a treatment for motor and non-motor features of Parkinson's disease (PD). Forty-six subjects receiving stable anti-Parkinsonian therapy were randomized to active (n = 23) or placebo (n = 23) treatment arms. Subjects self-administered CVS twice-daily over a period of 8 weeks at home via a portable, pre-programmed, solid-state ThermoNeuroModulation (TNM™) device delivering continually-varying thermal waveforms through aluminium ear-probes mounted on a wearable headset. Change scores from baseline to end of treatment and to a 1-month follow-up were determined using standardized clinical measures. The data presented here report sample demographics, detailed safety data and the statistical outcomes from the intention-to-treat and modified intention-to-treat analyses.

Indexed as

CognitionNeuro-rehabilitationNon-invasive brain stimulationSensory neuro-modulation

Identifiers

PMID31384641
PMCPMC6661455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.