Evidence map›Paper›PMID 31384529›Full record

ReviewActa pharmaceutica Sinica. B2019

Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application.

Qing Xia, Yongtai Zhang, Zhe Li, Xuefeng Hou, Nianping Feng

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 1 pooled it
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 1 synthesis or guideline pooled it, 618 citations in OpenAlex.

  1. Pooled it
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  17. HJournal of nanobiotechnology · 2026
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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qing XiaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yongtai ZhangDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhe LiDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xuefeng HouDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Nianping FengDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythrocytes (red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems (DDS) because of their features of biocompatibility, biodegradability, and long circulating half-life. Accordingly, a "camouflage" comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed, providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems.

Indexed as

ABC, accelerated blood clearanceAntitumorAPCs, antigen presenting cellsAuNCs, gold nanocagesAuNPs, gold nanoparticlesBiomimetic nanoparticlesC8bp, C8 binding proteinCR1, complement receptor 1DAF, decay accelerating factorDDS, drug delivery systemsDLS, dynamic light scatteringDox, doxorubicinDrug deliveryECM, extracellular matrixEpCam, epithelial cell adhesion moleculeEPR, enhanced permeability and retentionETA, endothelin AFA, folic acidGA, gambogic acidH&E, hematoxylin and eosinHRP, homologous restriction proteinMCP, membrane cofactor proteinMembraneMNCs, magnetic nanoclustersMNs, magnetic nanoparticlesMPS, mononuclear phagocyte systemMRI, magnetic resonance imagingMSNs, mesoporous silica nanoparticlesNanoparticlesNIR, near-infrared radiationPAI, photoacoustic imagingPBS, phosphate buffered salinePCL, poly(caprolactone)PDT, photodynamic therapyPEG, polyethylene glycolPFCs, perfluorocarbonsPLA, poly(lactide acid)PLGA, poly(d,l-lactide-co-glycolide)PPy, polypyrrolePS, photosensitizersPTT, photothermal therapyPTX, paclitaxelRBCM-NPs, RBCM-coated nanoparticlesRBCMs, RBC membranesRBCs, red blood cellsRed blood cellsRES, reticuloendothelial systemrHuPH20, recombinant hyaluronidase, PH20ROS, reactive oxygen speciesRVs, RBCM-derived vesiclesSEM, scanning electron microscopySIRPα, signal-regulatory protein alphaTEMPO, 2,2,6,6-tetramethylpiperidin-1-yl oxylTEM, transmission electron microscopyTPP, triphenylphosphoniumUCNPs, upconversion nanoparticlesUV, ultraviolet

Identifiers

PMID31384529
PMCPMC6663920
OpenAlexW2912471195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.