ArticleClinical kidney journal2019
Predicting long-term renal and patient survival by clinicopathological features in elderly patients undergoing a renal biopsy in a UK cohort.
Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Readability, Understandability, and Actionability of Online Cardiovascular Risk Assessment Tools and Patient Educational Material: A Systematic Review.Glomerular diseasesPooled it
- The Spectrum of Biopsy-Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study.Aging medicine (Milton (N.S.W)) · 2026Article
- Clinicopathological cohort study of kidney biopsy findings resulting in dialysis during long-term follow-up exceeding 30 years.Clinical and experimental nephrology · 2025Article
- Native kidney biopsies in older adults: disease spectrum, long-term kidney and patient survival and safety.International urology and nephrology · 2022Article
- Utility of interval kidney biopsy in ANCA-associated vasculitis.Rheumatology (Oxford, England) · 2022Article
- Nephrotic syndrome in the elderly: epidemiological aspects, clinical data, and renal biopsy findings.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Indications and considerations for kidney biopsy: an overview of clinical considerations for the non-specialist.Clinical medicine (London, England) · 2022Review
- Serum anti-CRP antibodies differentiate etiology and predict relapse in acute tubulointerstitial nephritis.Clinical kidney journal · 2022Article
- Long-term renal survival and related risk factors for primary membranous nephropathy in Chinese children: a retrospective analysis of 217 cases.Journal of nephrology · 2021Article
- Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group.Clinical and experimental nephrology · 2021Article
- Low-dose corticosteroid with mizoribine might be an effective therapy for elderly-onset ISKDC grade VI IgA vasculitis.CEN case reports · 2021Article
- The elderly with renal disease undergoing kidney biopsy-an opportunity for vaccination?Clinical kidney journal · 2020Article
- Article
- Kidney Biopsy in 613 Elderly Brazilian Patients: Clinicopathological Correlations.Glomerular diseasesArticle
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Abstract
backgroundSeveral publications have demonstrated the use of renal biopsy in elderly patients in establishing a diagnosis and enabling directed therapy. However, evidence on the long-term outcomes following biopsies is lacking. The aim of this study is to describe the renal and patient outcomes in elderly patients according to indication for biopsy, clinical parameters and the histological diagnosis.
methodsWe performed a retrospective cohort study of 463 patients >70 years old who underwent a renal biopsy at our centre between 2006 and 2015.
resultsThe median age of the patients was 74.8 (range 70.0-89.6) years. The most frequent primary diagnoses were pauci-immune crescentic glomerulonephritis (GN; 12%), acute interstitial nephritis (10.8%) and membranous GN (7.1%). Death-censored renal survival at 1 and 5 years following the index biopsy was 85.2 and 75.9%, respectively, and patient survival at 1 and 5 years was 92.2 and 71.6%, respectively. Patients who progressed to end-stage renal disease (ESRD) were at higher risk of dying compared with patients who did not require dialysis [hazard ratio 2.41 (95% confidence interval 1.58-3.68; P < 0.001]. On multivariate analysis, factors associated with the risk of progression to ESRD were creatinine (P < 0.001), heavy proteinuria (P = 0.002) and a non-chronic kidney disease (CKD) biopsy indication (P = 0.006). A histological diagnosis of primary GN (P = 0.001) or tubulointerstitial nephritis (P = 0.008) was associated with a favourable renal outcome, while patients with vasculitis and paraprotein-related renal disease (PPRD) had the highest risk of requiring dialysis (P = 0.0002 and P = 0.003, respectively). PPRD was also an independent risk factor for death.
conclusionsThis study demonstrates that renal biopsies in the elderly not only enable directed therapy, but also provide prognostic information on renal and patient survival.
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