ArticleProceedings (Baylor University. Medical Center)2019
Barriers to the utilization of genetic testing and genetic counseling in patients with suspected hereditary breast and ovarian cancers.
Article in Proceedings (Baylor University. Medical Center), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06436157 (Genetic Testing Uptake Through an Enhanced Oncology Nurse-Led Intervention in Patients With Solid Tumors), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Testing Uptake Through an Enhanced Oncology Nurse-Led Intervention in Patients With Solid Tumors (GENESIS): A Pilot Study
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Genetic counseling and testing for Asian Americans: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Pooled it
- Awareness, Attitudes, and Expectations of Indian Cancer Patients and Their Caregivers on Hereditary Cancers and Genetic Testing at a Tertiary Cancer Centre in India.Journal of genetic counseling · 2026Article
- Feasibility and acceptability of an electronic decision aid for genetic testing in ovarian and pancreatic cancer patients.Research connections · 2026Article
- The association of genetic testing timing and mutation type on breast cancer management in patients with breast cancer-related mutations.American journal of surgery · 2025Article
- Article
- A practical method for integrating community priorities in planning and implementing cancer control programs.Cancer causes & control : CCC · 2023Article
- Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon.American journal of human genetics · 2023Article
- The effect of genetic education on the referral of patients to genetic evaluation: Findings from a national survey of nephrologists.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing.JCO global oncology · 2023Article
- Feasibility of cancer genetic counselling and screening in Cameroon: perceived benefits and barriers.Ecancermedicalscience · 2023Article
- Toward a More Just System of Care in Molecular Pathology.The Milbank quarterly · 2022Article
- Comparison of Germline Genetic Testing Before and After a Medical Policy Covering Universal Testing Among Patients With Colorectal Cancer.JAMA network open · 2022Article
- Association between Health Insurance Type and Genetic Testing and/or Counseling for Breast and Ovarian Cancer.Journal of personalized medicine · 2022Article
- Postgraduate training in Cancer Genetics-a cross-specialty survey exploring experience of clinicians in Ireland.Irish journal of medical science · 2022Article
- Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology.Cancer treatment reviews · 2022Review
- Demographic Barriers for Genetic Testing in High-Risk Breast Cancer Patients in the Northern Michigan Area.Cureus · 2022Article
- Targeted BRCA1/2 population screening among Ashkenazi Jewish individuals using a web-enabled medical model: An observational cohort study.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Observational
- Impact of changing guidelines on genetic testing and surveillance recommendations in a contemporary cohort of breast cancer survivors with family history of pancreatic cancer.Scientific reports · 2021Article
- Barriers and Facilitators to Genetic Service Delivery Models: Scoping Review.Interactive journal of medical research · 2021Article
- Strategies to enhance identification of hereditary breast cancer gene carriers.Expert review of molecular diagnostics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A heritable condition is the identified cause of cancer in 5% to 10% of women with breast cancer and in 25% of women with ovarian cancer. It is critical to identify patients at risk for inherited genetic mutations to implement risk-reducing screening and interventions; however, reports in the medical literature indicate that an alarming number of patients with inherited genetic mutations do not receive recommended genetic counseling, testing, or interventions. In order to improve outcomes for these high-risk patients, barriers to genetic testing and counseling must be identified. We analyzed approximately 200 patients seen at our institution with breast or ovarian cancer who met criteria of the National Comprehensive Cancer Network for genetic counseling and testing. Of these patients, almost 70% had appropriate genetic testing and counseling. Review of the remaining 30% revealed that the largest obstacle to receiving genetic testing and/or counseling was lack of referral from the treating oncologist. Of the patients diagnosed with a pathogenic heritable mutation, most underwent appropriate risk-reducing procedures and surveillance. Thus, the initial referral to genetic counseling is the most significant barrier for at-risk patients at our institution and likely in this population at large. Additional study is needed to identify ways to improve appropriate use of genetic testing and counseling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.