ArticleProceedings of SPIE--the International Society for Optical Engineering2019
Quantitative Cone-Beam CT of Bone Mineral Density Using Model-Based Reconstruction.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Analysis of cervical bone mineral density in children and adolescents using cone beam computed tomography combined with liquid phantoms.Scientific reports · 2025Article
- Validation of bone mineral density measurement using quantitative CBCT image based on deep learning.Scientific reports · 2023Article
- Flat-panel conebeam CT in the clinic: history and current state.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Model-based dual-energy tomographic image reconstruction of objects containing known metal components.Physics in medicine and biology · 2020Article
- Reliability of Grayscale Value for Bone Density Determination in Oral Rehabilitation using Dental Implants.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeWe develop and validate a model-based framework for artifact correction and image reconstruction to enable application of Cone-Beam CT (CBCT) in quantitative assessment of bone mineral density (BMD). Compared to conventional quantitative CT, this approach does not require a BMD calibration phantom in the field-of-view during an object scan.
methodsThe quantitative CBCT (qCBCT) imaging framework combined fast Monte Carlo (MC) scatter estimation, accurate models of detector response, and polyenergetic Poisson likelihood (PolyPL, Elbakri
resultsThe PolyPL framework achieved accuracy of 20 mg/mL or better across all insert densities and experimental configurations. By comparison, the accuracy of the FDK-based BMD estimates deteriorated with higher mineralization, resulting in ~120 mg/mL error for a 500 mg/mL Ca insert. Additionally, the model-based approach mitigated residual streaks that were present in FDK reconstructions. The CV of both methods was ~15% at 50 mg/mL Ca and less than ~8% for higher density inserts, where the PolyPL framework achieved 20-25% lower CV than the FDK-based approach.
conclusionAccurate and reproducible BMD measurements can be achieved in extremity CBCT, supporting clinical applications in quantitative monitoring of fracture risk, osteoporosis treatment, and early osteoarthritis.
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