Evidence map›Paper›PMID 31384057›Full record

ArticleNature immunology2019

Functional reprogramming of regulatory T cells in the absence of Foxp3.

Louis-Marie Charbonnier, Ye Cui, Emmanuel Stephen-Victor, Hani Harb, David Lopez, Jack J Bleesing, Maria I Garcia-Lloret, Karin Chen, Ahmet Ozen, Peter Carmeliet and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 138 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. International journal of molecular sciences · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Can we cure autoimmunity?Current opinion in immunology · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. The 'TNature reviews. Rheumatology · 2025
    Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Louis-Marie CharbonnierDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Ye CuiDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Emmanuel Stephen-VictorDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Hani HarbDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8218-2538
David LopezDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Jack J BleesingDivision of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Maria I Garcia-LloretDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Karin ChenDivision of Allergy and Immunology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Ahmet OzenDivision of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-9065-1901
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Ming O LiImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9355-9564
Talal A ChatilaDivision of Immunology, Boston Children's Hospital, Boston, MA, USA. talal.chatila@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-7439-2762
Boston Children's Hospital · USUniversity of California, Los Angeles · USCincinnati Children's Hospital Medical Center · USMarmara University · TRMemorial Sloan Kettering Cancer Center · USUniversity of Utah · USVIB-KU Leuven Center for Cancer Biology · BE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
Molecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9M
Nutrient Sensing and mTORC1 Signaling in the Control of Regulatory T Cell Generation and FunctionR01AI102888 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI LI, MING · 2014 to 2022
$4.3M
Mechanisms of Disease Pathogenesis in Regulatory T cell DeficiencyR01AI085090 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHATILA, TALAL AMINE, WILLIAMS, CALVIN B · 2010 to 2020
$3.9M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016042NIAID NIH HHS R01 AI065617NIAID NIH HHS R01 AI085090NIAID NIH HHS R01 AI102888NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

AnimalsCells, CulturedCellular ReprogrammingFemaleForkhead Transcription FactorsGene Expression RegulationGlycolysisHumansMaleMechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLMice, KnockoutOxidative PhosphorylationRapamycin-Insensitive Companion of mTOR ProteinSignal TransductionForkhead Transcription FactorsFOXP3 protein, humanMechanistic Target of Rapamycin Complex 2Rapamycin-Insensitive Companion of mTOR Proteinrictor protein, mouse

Identifiers

PMID31384057
PMCPMC6707855
OpenAlexW2966678440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.