Evidence map›Paper›PMID 31383950›Full record

ArticleSpinal cord2019

Clinical associations with telomere length in chronic spinal cord injury.

David M Monroe, Rebekah L Goldstein, Merilee A Teylan, Jaime E Hart, Immaculata DeVivo, Esther H Orr, Eric Garshick

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

David M MonroeTufts University School of Medicine, Boston, MA, USA.
Rebekah L GoldsteinResearch and Development Service, VA Boston Healthcare System, West Roxbury, MA, USA.
Merilee A TeylanResearch and Development Service, VA Boston Healthcare System, West Roxbury, MA, USA.
Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Immaculata DeVivoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Esther H OrrBrigham and Women's Hospital and Dept of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Eric GarshickPulmonary, Allergy, Sleep and Critical Care Medicine Section, VA Boston Healthcare System and Harvard Medical School, West Roxbury, MA, USA. Eric.Garshick@va.gov.
VA Boston Healthcare System · USBrigham and Women's Hospital · USHarvard University · USTufts University · US

Funding

Adiposity and Bone Loss in Spinal Cord InjuryR01AR059270 · NIAMS · SPAULDING REHABILITATION HOSPITAL · PI MORSE, LESLIE R. · 2010 to 2014
$3.0M
Vitamin D, Respiratory Function, and Illness in Chronic SCII01RX000792 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GARSHICK, ERIC · 2014 to 2016
–
Determinants of Telomere Length in Chronic SCI: A Pilot StudyI21RX000596 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GARSHICK, ERIC · 2012 to 2015
–
DENDRITIC CELLS AND HIV-1 PATHOGENESISR03TW000792 · FIC · ROCKEFELLER UNIVERSITY · PI STEINMAN, RALPH M. · 1997 to 1999
–
NIAMS NIH HHS R01 AR059270RRD VA I01 RX000792RRD VA I21 RX000596VHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development) B6618RVHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development) I01RX000596VHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development) I01RX000792
6 · The paper itself

Abstract

STUDY

designCross-sectional study

objectivesTo determine clinical factors associated with telomere length in persons with chronic spinal cord injury (SCI).

settingVeterans Affairs Medical Center, Boston, MA.

methodsTwo hundred seventy-eight participants with chronic SCI provided blood samples for measurement of C-reactive protein (CRP), interleukin-6 (IL-6), and telomere length, completed respiratory health questionnaires, underwent dual X-ray absorptiometry (DXA) to assess body fat, and completed spirometry. High-throughput real-time PCR assays were used to assess telomere length in leukocyte genomic DNA. Linear regression models were used to assess cross-sectional associations with telomere length.

resultsTelomere length was inversely related to age (p < 0.0001). In age-adjusted models, gender, race, injury duration, %-total and %-trunk fat, body mass index (BMI), %-predicted forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV

conclusionsOur results suggest that clinical characteristics such as decreased mobility and bladder dysfunction that are common in individuals with more severe SCI are associated with shorter telomere length.

Indexed as

AdultAgedAged, 80 and overAge FactorsChronic DiseaseCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedMobility LimitationSpinal Cord InjuriesTelomereTelomere HomeostasisUrinary Bladder Diseases

Identifiers

PMID31383950
PMCPMC6940383
OpenAlexW2966234296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.