ArticleTranslational psychiatry2019
Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex.Science advances · 2025Article
- Resting-state EEG power and machine-learning classification in adult males with gambling disorder.Frontiers in human neuroscience · 2025Article
- Patterns and predictors of orbitofrontal sulcogyral morphology in a nonclinical population.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Volumetric Variability of the Ventromedial Prefrontal Cortex Reflects the Propensity for Engaging in High-Stakes Gambling Behavior.Brain sciences · 2022Article
- Theta low-gamma phase amplitude coupling in the human orbitofrontal cortex increases during a conflict-processing task.Journal of neural engineering · 2022Article
- Scan Once, Analyse Many: Using Large Open-Access Neuroimaging Datasets to Understand the Brain.Neuroinformatics · 2022Article
- Orbitofrontal sulcogyral morphology in patients with cocaine use disorder.Psychiatry research. Neuroimaging · 2020Article
- Orbitofrontal Sulcogyral Pattern as a Transdiagnostic Trait Marker of Early Neurodevelopment in the Social Brain.Clinical EEG and neuroscience · 2020Review
- Gambling Dual Disorder: A Dual Disorder and Clinical Neuroscience Perspective.Frontiers in psychiatry · 2020Review
- Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Examining neural reactivity to gambling cues in the age of online betting.Current behavioral neuroscience reports · 2019Article
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Authors and funding
15 authors at 10 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Types I, II, and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sulcogyral patterns in gambling disorder and suggest that pattern Type II might represent a pre-morbid structural brain marker of the disease. It will be important to investigate more closely the functional implications of these structural abnormalities in future work.
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