Evidence map›Paper›PMID 31383789›Full record

ArticleBioscience reports2019

Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status.

Lin Zhou, Jinhua Zhou, Bin Sheng, Xin Li, Youchao Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. USP7 Inhibition Alleviates HFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lin ZhouDepartment of Clinical Laboratory, Hunan Provincial People's Hospital, The First Hospital of Hunan Normal University, No. 61 Jiefang West Road, Changsha 410000, Hunan, China.
Jinhua ZhouDepartment of Orthopedics, Hunan Provincial People's Hospital, The First Hospital of Hunan Normal Universtiy, No. 61 Jiefang West Road, Changsha 410000, Hunan, China.
Bin ShengDepartment of Orthopedics, Hunan Provincial People's Hospital, The First Hospital of Hunan Normal Universtiy, No. 61 Jiefang West Road, Changsha 410000, Hunan, China ShengBin217@163.com.ORCID 0000-0003-1914-4787
Xin LiDepartment of Orthopedics, Hunan Provincial People's Hospital, The First Hospital of Hunan Normal Universtiy, No. 61 Jiefang West Road, Changsha 410000, Hunan, China.
Youchao YuanDepartment of Orthopedics, Hunan Provincial People's Hospital, The First Hospital of Hunan Normal Universtiy, No. 61 Jiefang West Road, Changsha 410000, Hunan, China.
Hunan Provincial People's Hospital · CNHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine (Dex) is an anesthetic widely used in lumbar discectomy, but its effect on chondrocytes remains unclear. Dex is speculated to promote cartilage degeneration by activating α-2 adrenergic receptor. However, the antioxidative and anti-inflammatory effects of Dex implied the potential chondrocyte protective effect under stress conditions. The present study aimed to determine the effect of Dex on chondrocytes under non-stress and stress conditions. Chondrocytes were isolated from human annulus fibrosus (AF) tissues and oxidative stress was induced by treatment with 1 mM hydrogen peroxide (H

Indexed as

AdultAnnulus FibrosusChondrocytesCollagen Type IIDexmedetomidineFemaleGene Expression RegulationHumansHydrogen PeroxideMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 13Matrix Metalloproteinase 3Middle AgedNedd4 Ubiquitin Protein LigasesNLR Family, Pyrin Domain-Containing 3 ProteinCOL2A1 protein, humanCollagen Type IIDexmedetomidineHydrogen PeroxideMatrix Metalloproteinase 13Matrix Metalloproteinase 3MMP13 protein, humanMMP3 protein, humanNedd4 protein, humanNedd4 Ubiquitin Protein LigasesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanXIAP protein, humanX-Linked Inhibitor of Apoptosis Proteinannulus fibrosus chondrocytescartilage degenerationDexmedetomidineNF-κBNLRP3XIAP

Identifiers

PMID31383789
PMCPMC6706599
OpenAlexW2965912939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.