Evidence map›Paper›PMID 31383746›Full record

ArticleInfection and immunity2019

Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms.

K Ellepola, T Truong, Y Liu, Q Lin, T K Lim, Y M Lee, T Cao, H Koo, C J Seneviratne

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Artemisinins inhibited the synergistic cariogenic effect betweenFrontiers in cellular and infection microbiology · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Effect ofJournal of dental research · 2025
    Article
  11. Article
  12. Article
  13. Microorganisms · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Multifaceted roles ofFrontiers in cellular and infection microbiology · 2025
    Review
  20. Frontiers in microbiology · 2025
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

K EllepolaOral Sciences, Faculty of Dentistry, National University of Singapore, Singapore.ORCID 0000-0003-3806-9807
T TruongOral Sciences, Faculty of Dentistry, National University of Singapore, Singapore.
Y LiuBiofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Q LinProtein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore.
T K LimProtein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore.
Y M LeeProtein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore.
T CaoOral Sciences, Faculty of Dentistry, National University of Singapore, Singapore.
H KooBiofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA koohy@dental.upenn.edu jaya.seneviratne@ndcs.com.sg.ORCID 0000-0001-9143-2076
C J SeneviratneNational Dental Centre Singapore, Oral Health ACP, SingHealth Duke NUS, Singapore koohy@dental.upenn.edu jaya.seneviratne@ndcs.com.sg.
National University of Singapore · SGUniversity of Pennsylvania · USSingHealth · SG

Funding

S. mutans-C. albicans interactions synergize the virulence of cariogenic biofilmsR01DE025220 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2015 to 2019
$2.0M
NIDCR NIH HHS R01 DE025220
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, BacterialGene Expression Regulation, FungalTranscriptomeBacterial ProteinsBiofilmsCandida albicansCarbohydrate MetabolismCell WallChildCoculture TechniquesDental CariesGlucansGlucosyltransferasesHumansProteomicsStreptococcus mutans1,3-alpha-D-glucan synthaseBacterial ProteinsGlucansGlucosyltransferasesCandida albicansearly-childhood cariesmixed-species biofilmsomicsStreptococcus mutans

Identifiers

PMID31383746
PMCPMC6759298
OpenAlexW2965166374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.