SynthesisJournal of the American Society of Nephrology : JASN2019
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Application of causal inference methods in individual-participant data meta-analyses in medicine: addressing data handling and reporting gaps with new proposed reporting guidelines.BMC medical research methodology · 2024Pooled it
- Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.Kidney international · 2020Pooled it
- Update on APOL1 and chronic kidney diseases in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Epidemiology of cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2025Article
- Apolipoproteins in Chronic Kidney Disease and Kidney Transplant: A Long Unfinished Story.International journal of molecular sciences · 2025Review
- Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population.Human genomics · 2025Article
- Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice.Clinical science (London, England : 1979) · 2025Article
- Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- The metabolic effects of APOL1 in humans.Pflugers Archiv : European journal of physiology · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.Nature reviews. Nephrology · 2022Review
- APOL1 G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry.Cardiorenal medicine · 2022Article
- Establishment and Validation of a Tumor Microenvironment Prognostic Model for Predicting Bladder Cancer Survival Status Based on Integrated Bioinformatics Analyses.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis.BMC cancer · 2021Article
- Article
- APOL1 at 10 years: progress and next steps.Kidney international · 2021Article
- A brief introduction of meta-analyses in clinical practice and research.The journal of gene medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 16 institutions in 1 country.
Morgan E GramsDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; mgrams2@jhmi.edu.
Aditya SurapaneniWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Shoshana H BallewWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Lawrence J AppelWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Eric BoerwinkleHuman Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas.
L Ebony BoulwareDivision of General Internal Medicine, Duke University School of Medicine, Durham, North Carolina.
Teresa K ChenDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Josef CoreshWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland.ORCID 0000-0002-4598-0669
Mary CushmanDepartments of Medicine and.
Jasmin DiversDepartment of Biostatistics and Data Science, Division of Public Health Sciences and.
Orlando M GutiérrezDepartments of Medicine and.
Marguerite R IrvinDepartments of Medicine and.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, California.
Jeffrey B KoppKidney Diseases Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Lewis H KullerDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Carl D LangefeldDepartment of Biostatistics and Data Science, Division of Public Health Sciences and.
Michael S LipkowitzDivision of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC.
Kenneth J MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Solomon K MusaniDepartment of Medicine and.
Rakhi P NaikDepartment of Medicine, Division of Hematology, Johns Hopkins Medicine, Baltimore, Maryland.
Nicholas M PajewskiDepartment of Biostatistics and Data Science, Division of Public Health Sciences and.
Carmen A PeraltaKidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, California.
Adrienne TinWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland.ORCID 0000-0002-4207-5866
Christina L WasselPremier Applied Sciences, Premier, Inc., Charlotte, North Carolina.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Cheryl A WinklerMolecular Genetic Epidemiology Section, Basic Research Laboratory, Basic Science Program, National Cancer Institute Leidos Biomedical Research, Frederick National Laboratory, Frederick, Maryland.
Bessie A YoungDivision of Nephrology, Veterans Affairs Puget Sound Health Care Center, Seattle, Washington; and.
Neil A ZakaiDepartments of Medicine and.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Johns Hopkins University · USUniversity of Alabama at Birmingham · USUniversity of Vermont · USBeth Israel Deaconess Medical Center · USDuke University · USGeorgetown University · USLeidos (United States) · USNational Institutes of Health · USPremier Research Group · USSan Francisco VA Medical Center · USThe University of Texas Health Science Center at Houston · USUniversity of California San Diego · USUniversity of Mississippi Medical Center · USUniversity of Pittsburgh · USUniversity of Washington · USWake Forest University · US
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MRenal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8MFocal Segmental Glomerulosclerosis: Genetics & MechanismsZIADK043308 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$15.7MChronic Kidney Disease Prognosis Consortium (CKD-PC)R01DK100446 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, Morgan Erika Grams · 2014 to 2026
$10.7MMulti-Omics and Chronic Kidney Disease: Correlation with HistologyR01DK108803 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Morgan Erika Grams, EUGENE P. RHEE · 2016 to 2026
$6.4MBiomarkers of Immune Activation in African Americans with CKDK08DK117068 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, TERESA · 2019 to 2023
$961kCKD-Targeted Analyses of the Jackson Heart StudyR01DK102134 · NIDDK · UNIVERSITY OF WASHINGTON · PI YOUNG, BESSIE ANN · 2013 to 2015
$829kNIDDK NIH HHS K08 DK117068NIDDK NIH HHS P30 DK079310NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK100446NIDDK NIH HHS R01 DK102134NIDDK NIH HHS R01 DK108803
Abstract
backgroundTwo coding variants in the apo L1 gene (
methodsWe conducted a two-stage individual participant data meta-analysis to assess the association of
resultsOver 8.9±5.0 years of follow-up, 2076 incident cardiovascular disease events occurred in the 16,216 participants who did not have cardiovascular disease at study enrollment. In fully-adjusted analyses, individuals possessing two
conclusionsIn this large, two-stage individual participant data meta-analysis,
Indexed as
Apolipoprotein L1Black or African AmericanCardiovascular DiseasesGenetic VariationHumansKidney DiseasesRisk AssessmentAPOL1 protein, humanApolipoprotein L1APOL1Blackscardiovascular diseasedeathkidney diseasemeta-analysis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.