ArticleeNeuro
Right Structural and Functional Reorganization in Four-Year-Old Children with Perinatal Arterial Ischemic Stroke Predict Language Production.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging and Neurological Outcomes in Perinatal Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis.Pediatric neurology · 2024Pooled it
- Long-Term Cognitive and Language Outcomes at the Age of Seven Following Arterial Presumed Perinatal Ischemic Stroke: A Case Report.Brain sciences · 2025Article
- White matter microstructure in language tracts in youth with perinatal stroke.Brain imaging and behavior · 2025Article
- Functional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke.Human brain mapping · 2025Article
- Assessing the Early Lateralization of White Matter in the Infant Language Network.Human brain mapping · 2025Article
- Neuroimaging and Emotional Development in the Pediatric Population: Understanding the Link Between the Brain, Emotions, and Behavior.Pediatric reports · 2025Review
- How Can Graph Theory Inform the Dual-stream Model of Speech Processing? A Resting-state Functional Magnetic Resonance Imaging Study of Stroke and Aphasia Symptomology.Journal of cognitive neuroscience · 2025Article
- Arterial Presumed Perinatal Ischemic Stroke: A Mini Review and Case Report of Cognitive and Speech-Language Profiles in a 5-Year-Old Girl.Children (Basel, Switzerland) · 2023Article
- One right can make a left: sentence processing in the right hemisphere after perinatal stroke.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Language Exposure and Brain Myelination in Early Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Language and Cognitive Outcomes Following Ischemic Stroke in Children With Monolingual and Bilingual Exposure.Journal of child neurology · 2023Article
- The right uncinate fasciculus supports verbal short-term memory in aphasia.Brain structure & function · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Plasticity of the language system in children and adults.Handbook of clinical neurology · 2022Review
- Precise neonatal arterial ischemic stroke classification with a three-dimensional map of the arterial territories of the neonatal brain.Pediatric research · 2020Article
- Structural and functional connectivity of motor circuits after perinatal stroke: A machine learning study.NeuroImage. Clinical · 2020Article
- Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy.Frontiers in pharmacology · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of four-year-old children with left perinatal arterial ischemic stroke (PAIS). Specifically, we gathered specific fine-grained developmental measures of receptive and productive aspects of language as well as standardized measures of cognitive development. We also collected structural neuroimaging data as well as functional activations during a passive listening story-telling fMRI task and a resting state session (rs-fMRI). Children with a left perinatal stroke showed larger lateralization indices of both structural and functional connectivity of the dorsal language pathway towards the right hemisphere that, in turn, were associated with better language outcomes. Importantly, the pattern of structural asymmetry was significantly more right-lateralized in children with a left perinatal brain insult than in a group of matched healthy controls. These results strongly suggest that early lesions of the left dorsal pathway and the associated perisylvian regions can induce the interhemispheric transfer of language functions to right homolog regions. This study provides combined evidence of structural and functional brain reorganization of language networks after early stroke with strong implications for neurobiological models of language development.
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