Evidence map›Paper›PMID 31383660›Full record

ArticleAntimicrobial agents and chemotherapy2019

Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.

Andrew T Nishimoto, Sarah G Whaley, Nathan P Wiederhold, Qing Zhang, Christopher M Yates, William J Hoekstra, Robert J Schotzinger, Edward P Garvey, P David Rogers

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Mechanism of azole resistance inJournal of medical microbiology · 2025
    Article
  3. Review
  4. Antifungal Drug Resistance.Current topics in microbiology and immunology · 2025
    Review
  5. Evaluation of Fifteen 5,6-Dihydrotetrazolo[1,5-Journal of fungi (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Identification of Potent and Selective Inhibitors ofJournal of medicinal chemistry · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Antifungal Resistance among Less PrevalentJournal of fungi (Basel, Switzerland) · 2021
    Review
  15. Antifungal Pipeline.Frontiers in cellular and infection microbiology · 2021
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrew T NishimotoUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.
Sarah G WhaleyUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0001-5851-0490
Nathan P WiederholdUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-2225-5122
Qing ZhangUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.
Christopher M YatesViamet Pharmaceuticals Inc., Durham, North Carolina, USA.
William J HoekstraViamet Pharmaceuticals Inc., Durham, North Carolina, USA.
Robert J SchotzingerViamet Pharmaceuticals Inc., Durham, North Carolina, USA.
Edward P GarveyViamet Pharmaceuticals Inc., Durham, North Carolina, USA.
P David RogersUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA drogers@uthsc.edu.
University of Tennessee Health Science Center · USViamet Pharmaceuticals (United States) · USThe University of Texas Health Science Center at San Antonio · US

Funding

Upc2A: A Central Regulator and "Achilles' Heel" of Fluconazole Resistance in Candida glabrataR01AI131620 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ROGERS, P. DAVID · 2017 to 2021
$2.7M
NIAID NIH HHS R01 AI131620
6 · The paper itself

Abstract

VT-1161 and VT-1598 are promising investigational tetrazole antifungals that have shown

Indexed as

Antifungal AgentsCandida glabrataDrug Resistance, FungalFungal ProteinsMicrobial Sensitivity TestsPyridinesTetrazolesTranscription FactorsAntifungal AgentsFungal ProteinsPyridinesTetrazolesTranscription FactorsVT-1161VT-1598antifungal resistanceazole antifungalsCandida glabratatetrazole

Identifiers

PMID31383660
PMCPMC6761532
OpenAlexW2966463840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.