Evidence map›Paper›PMID 31383656›Full record

Trial reportAntimicrobial agents and chemotherapy2019

Helmi Pett, John Bradley, Joseph Okebe, Alassane Dicko, Alfred B Tiono, Bronner P Gonçalves, Will Stone, Ingrid Chen, Kjerstin Lanke, Mikko Neuvonen and 7 more

Open access · hybridAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Delayed gametocyte clearance inAntimicrobial agents and chemotherapy · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 7 countries.

Helmi Pett *Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
John Bradley *MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Joseph OkebeMedical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Banjul, the Gambia.
Alassane DickoMalaria Research and Training Centre, Faculty of Pharmacy and Faculty of Medicine and Dentistry, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.
Alfred B TionoPublic Health Department, Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
Bronner P GonçalvesDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Will StoneDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ingrid ChenMalaria Elimination Initiative, Global Health Group, University of California, San Francisco, San Francisco, California, USA.
Kjerstin LankeRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Mikko NeuvonenDepartment of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anna-Liina MustaniemiDepartment of Forensic Medicine, University of Helsinki, Helsinki, Finland.
Alice C EziefulaDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Roly GoslingMalaria Elimination Initiative, Global Health Group, University of California, San Francisco, San Francisco, California, USA.
Umberto D'AlessandroMedical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Banjul, the Gambia.
Chris DrakeleyDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Mikko NiemiDepartment of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Teun BousemaRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands teun.bousema@radboudumc.nl.ORCID 0000-0003-2666-094X
London School of Hygiene & Tropical Medicine · GBUniversity of Helsinki · FIMRC Unit the Gambia · GMRadboud University Nijmegen · NLUniversity of California, San Francisco · USBrighton and Sussex Medical School · GBCentre National de Recherche et de Formation sur le Paludisme · BFUniversity of Bamako · ML

Funding

Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

Single-dose primaquine (PQ) clears mature gametocytes and reduces the transmission of

Indexed as

Polymorphism, GeneticAdultAfricaAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsChildCytochrome P-450 CYP2D6Drug Administration ScheduleFemaleGene ExpressionGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHumansLife Cycle StagesMalaria, FalciparumAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsartenimolCytochrome P-450 CYP2D6Glucosephosphate DehydrogenasepiperaquinePiperazinesPrimaquineQuinolinescytochrome P450drug metabolismeliminationgametocytegenetic polymorphismsmalariametaboliteprimaquinesafetytransmission

Identifiers

PMID31383656
PMCPMC6761544
OpenAlexW2966490109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.