ArticleCancer research2019
SNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- DTX3L Inhibits the EMT, Metastasis, and Stem-Like Features of Gastric Cancer Through Promoting GSK-3β Dependent SNAI1 Decay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Decoding the Snail transcriptional network: its role in cancer progression and therapy.Biology direct · 2026Review
- RASGEF1B suppresses hepatocellular carcinoma through the ALDH7A1/Betaine/SNAI1 metabolic‒epigenetic axis.Journal of translational medicine · 2026Article
- Uncoupling Metastasis and Epithelial-to-Mesenchymal Transition in sgP19/kRAS-Driven Spontaneous Metastatic Liver Tumor Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ECM stiffness governs endothelial barrier integrity through YAP-mediated stabilization of ZO-1.Bioactive materials · 2026Article
- CD34Journal of advanced research · 2025Article
- Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review).International journal of oncology · 2024Review
- Atractylodin and β-eudesmol from Atractylodes lancea (Thunb.) DC. Inhibit Cholangiocarcinoma Cell Proliferation by Downregulating the Notch Signaling Pathway.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Cyanidin-3-O-Glucoside Induces the Apoptosis of Human Gastric Cancer MKN-45 Cells through ROS-Mediated Signaling Pathways.Molecules (Basel, Switzerland) · 2023Article
- Article
- DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD.Journal of biomedical science · 2022Article
- Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review).Molecular and clinical oncology · 2022Review
- Long-Term Hypoxia Maintains a State of Dedifferentiation and Enhanced Stemness in Fetal Cardiovascular Progenitor Cells.International journal of molecular sciences · 2021Article
- Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans.Hepatology (Baltimore, Md.) · 2021Article
- 18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells.OncoTargets and therapy · 2021Article
- The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans.The American journal of pathology · 2020Article
- Article
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Authors and funding
19 authors at 8 institutions in 5 countries.
Meng XuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, P. R. China.ORCID 0000-0001-7565-6053
Jingxiao WangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Zhong XuDepartment of Gastroenterology, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, P. R. China.ORCID 0000-0001-7565-6053
Rong LiDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
Pan WangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Runze ShangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Antonio CiglianoInstitute of Pathology, University Clinic of Regensburg, Regensburg, Germany.ORCID 0000-0002-6408-3613
Silvia RibbackInstitute of Pathology, University of Greifswald, Greifswald, Germany.
Antonio SolinasDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Giovanni Mario PesDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0003-3265-2823
Katja EvertInstitute of Pathology, University Clinic of Regensburg, Regensburg, Germany.
Haichuan WangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Xinhua SongDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Shu ZhangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Li CheDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Rosa Maria PascaleDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0001-7612-3646
Diego Francesco CalvisiInstitute of Pathology, University Clinic of Regensburg, Regensburg, Germany. liuqingguang@vip.sina.com diego.calvisi@klinik.uni-regensburg.de.
Qingguang LiuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, P. R. China. liuqingguang@vip.sina.com diego.calvisi@klinik.uni-regensburg.de.
Xin ChenDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
University of California, San Francisco · USUniversity of Sassari · ITUniversitätsmedizin Greifswald · DEUniversity Hospital Regensburg · DEBeijing University of Chinese Medicine · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNGuizhou Provincial People's Hospital · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN
Funding
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7MRole of Cancer-Associated Fibroblasts in CholangiocarcinomaR01CA228483 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, XIN, SCHWABE, ROBERT F. · 2018 to 2022
$3.1MMolecular Genetics of Liver CancersR01CA136606 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, XIN · 2009 to 2016
$2.6MSignaling cascades in cholangiocarcinoma developmentR01CA190606 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, XIN · 2016 to 2020
$1.8MNCI NIH HHS R01 CA136606NCI NIH HHS R01 CA190606NCI NIH HHS R01 CA228483NIDDK NIH HHS P30 DK026743
Abstract
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has limited treatment options. Snail family transcriptional repressor 1 (SNAI1) is a master regulator of epithelial-mesenchymal transition (EMT) and has been implicated in HCC initiation and progression. However, the precise role of SNAI1 and the way it contributes to hepatocarcinogenesis have not been investigated in depth, especially
Indexed as
AnimalsCadherinsCarcinoma, HepatocellularCell MovementCholangiocarcinomaDisease Models, AnimalEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMicePhenotypeProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-metSnail Family Transcription FactorsVimentinCadherinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-metSNAI1 protein, humanSnai1 protein, mouseSnail Family Transcription FactorsVimentin
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.