ArticleJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy2020
The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan.
Article in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of Point-of-Care Testing for Respiratory Pathogens on Antibiotic Use in Children: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Point-of-Care Multiplex NAAT for Acute Pharyngitis in the Urgent Care: Detection Patterns, Associated Antimicrobial Prescribing, and Stakeholder Perceptions.Open forum infectious diseases · 2026Article
- Amplicon-based sequencing as a diagnostic tool for severe pneumonia in the ICU.Scientific reports · 2026Article
- Article
- Rapid diagnosis of acute pediatric respiratory infections with Point-of-Care and multiplex molecular testing.Infection · 2025Review
- Integrating sequencing methods with machine learning for antimicrobial susceptibility testing in pediatric infections: current advances and future insights.Frontiers in microbiology · 2025Review
- Multiplex PCR and Antibiotic Use in Children with Community-Acquired Pneumonia.Children (Basel, Switzerland) · 2024Article
- Article
- Expanded PCR Panel Testing for Identification of Respiratory Pathogens and Coinfections in Influenza-like Illness.Diagnostics (Basel, Switzerland) · 2023Article
- Systematic review of economic evaluations for paediatric pulmonary diseases.Cost effectiveness and resource allocation : C/E · 2023Article
- Viral Identification Using Multiplex Polymerase Chain Reaction Testing Does Not Reduce Antibiotic Prescribing in Paediatric Intensive Care Units.Microorganisms · 2023Article
- Article
- Article
- Point-of-Care and Rapid Tests for the Etiological Diagnosis of Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Utility and Applicability of Rapid Diagnostic Testing in Antimicrobial Stewardship in the Asia-Pacific Region: A Delphi Consensus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Co-infection with Legionella and SARS-CoV-2: a case report.JA clinical reports · 2021Article
- Evaluation of Molecular Point-of-Care Testing for Respiratory Pathogens in Children With Respiratory Infections: A Retrospective Case-Control Study.Frontiers in cellular and infection microbiology · 2021Article
- Rapid and Point-of-Care Testing in Respiratory Tract Infections: An Antibiotic Guardian?ACS pharmacology & translational science · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid molecular diagnosis of infections has contributed to timely treatments and antimicrobial stewardship. However, the benefit and cost-effectiveness vary in each country or community because they have different standard practices and health care systems. In Japan, rapid antigen tests (RATs) have been frequently used for pediatric respiratory infections. We investigated the impact and cost-effectiveness of a multiplex PCR (mPCR) respiratory panel for pediatric respiratory infections in a Japanese community hospital.
methodsWe replaced RATs with an mPCR respiratory panel (FilmArray®) for admitted pediatric respiratory infections on March 26, 2018. We compared the days of antimicrobial therapy (DOT) and length of stay (LOS) during the mPCR period (March 2018 to April 2019) with those of the RAT period (March 2012 to March 2018).
resultsDuring the RAT and mPCR periods, 1132 and 149 patients were analyzed. The DOT/case was 12.82 vs 8.56 (p < 0.001), and the LOS was 8.18 vs 6.83 days (p = 0.032) in the RAT and mPCR groups, respectively. The total costs during admissions were ∖258,824 ($2331.7) and ∖243,841 ($2196.8)/case, respectively. Pathogen detection rates were 30.2% vs 87.2% (p < 0.001).
conclusionCompared to conventional RATs, the mPCR test contributed to a reduction in the DOT and LOS in a Japanese community hospital for admission-requiring pediatric respiratory infections. However, a proper stewardship program is essential to further reduce the unnecessary usage of antimicrobials.
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