Evidence map›Paper›PMID 31382919›Full record

ArticleBMC nephrology2019

Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus.

Jian Lu, Ze Bo Hu, Pei Pei Chen, Chen Chen Lu, Jia Xiu Zhang, Xue Qi Li, Ben Yin Yuan, Si Jia Huang, Kun Ling Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jian LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Ze Bo HuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Pei Pei ChenInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Chen Chen LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Jia Xiu ZhangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Xue Qi LiInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Ben Yin YuanInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Si Jia HuangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China.
Kun Ling MaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing City, 210009, Jiang Su Province, China. klma05@163.com.
Zhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte damage mediated by systemic lupus erythematosus (SLE) plays an important role in the pathogenesis and progression of lupus nephritis (LN). This study evaluated whether the podocyte-derived microparticles (MPs) were novel biomarkers of clinical and histological features in SLE patients with LN.

methodsA cross-sectional study, including 34 SLE patients and 16 healthy controls, was designed. Urinary annexin V

resultsThe number of annexin V

conclusionsThese findings suggest that the change in urinary podocyte-derived MP levels could be useful for evaluating and monitoring SLE disease activity.

Indexed as

Cell-Derived MicroparticlesPodocytesAnnexin A5Case-Control StudiesChi-Square DistributionCross-Sectional StudiesFemaleFlow CytometryHumansLupus Erythematosus, SystemicLupus NephritisMaleMiddle AgedROC CurveSialoglycoproteinsStatistics, NonparametricAnnexin A5podocalyxinSialoglycoproteinsPodocyte-derived microparticlesPodocyte injurySystemic lupus erythematosus

Identifiers

PMID31382919
PMCPMC6683479
OpenAlexW2964396002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.