Evidence map›Paper›PMID 31382901›Full record

ArticleBMC infectious diseases2019

Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program.

Jean Damascene Makuza, Carol Y Liu, Corneille Killy Ntihabose, Donatha Dushimiyimana, Sabine Umuraza, Marie Paul Nisingizwe, Justine Umutesi, Janvier Serumondo, Soline Dusabeyesu Mugeni, Muhamed Semakula and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Jean Damascene MakuzaIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda. makorofr@gmail.com.ORCID http://orcid.org/0000-0001-9275-8844
Carol Y LiuHealth Department, Clinton Health Access Initiative (CHAI), Kigali, Rwanda.
Corneille Killy NtihaboseIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Donatha DushimiyimanaIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Sabine UmurazaHealth Department, Clinton Health Access Initiative (CHAI), Kigali, Rwanda.
Marie Paul NisingizweSchool of Population and Public Health, University of British Columbia, Vancouver, Canada.
Justine UmutesiIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Janvier SerumondoIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Soline Dusabeyesu MugeniHealth Department, Clinton Health Access Initiative (CHAI), Kigali, Rwanda.
Muhamed SemakulaIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Neil GuptaDivision of Global Health Equity, Brigham & Women's Hospital, Boston, USA.
Margaret HellardDepartment of Infectious Disease at the Alfred Hospital and Infectious Diseases Epidemiology, Monash University in Melbourne, Melbourne, Australia.
Sabin NsanzimanaIHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
Rwanda Biomedical Center · RWBrigham and Women's Hospital · USMonash University · AUUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe epidemiology and risk factors for hepatitis C virus (HCV) infection in Rwanda are not well known; however, this information is crucial to shaping the country's public health approach to hepatitis C control.

methodsA HCV screening campaign was conducted in the general population in 24 districts previously identified to have a high HCV disease burden. At the time of sample collection, sociodemographic information and self-reported risk factors were collected. Bivariate and multivariate logistic regressions were conducted to assess risk factors independently associated with hepatitis C antibodies (HCVAb) seroprevalence.

resultsOut of a total of 326,263 individuals screened for HCVAb, 22,183 (6.8%) were positive. In multivariate analysis, risk factors identified as statistically associated with HCVAb Seroprevalence include history of traditional operation or scarification (OR = 1.09, 95% CI: 1.05-1.14), presence of viral hepatitis in the family (OR = 1.27, 95% CI: 1.15-1.40), widowed or separated/divorced (OR = 1.36, 95% CI: 1.26-1.47), Southern province (OR = 1.98, 95% CI: 1.88-2.08) and aged 65 years and older (OR = 4.86, 95% CI: 4.62-5.11). Ubudehe category 3 (OR = 0.97, 95% CI: 0.93-1.01) and participants using RAMA (Health insurances for employees of public and private sectors) insurance (OR = 0.76, 95% CI: 0.70-0.85) had lower odds of HCV seroprevalence.

conclusionsOur findings provide important information for Rwanda's strategy on prevention and case-finding. Future prevention interventions should aim to reduce transmission through targeted messaging around traditional healing practices and case-finding targeting individuals with a history of exposure or advanced age.

Indexed as

AdultAgedCross-Sectional StudiesFemaleHepatitis CHepatitis C AntibodiesHumansLogistic ModelsMaleMass ScreeningMiddle AgedMultivariate AnalysisRisk FactorsRwandaSeroepidemiologic StudiesHepatitis C AntibodiesRisk factorsRwandaViral hepatitis C

Identifiers

PMID31382901
PMCPMC6683524
OpenAlexW2964675677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.