ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Imaging effective oxygen diffusivity in the human brain with multiparametric magnetic resonance imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.NeuroImage · 2026Article
- Explainable multi-modal approach for uncovering key predictors of stroke-risk from ECG, EMG, blood pressure, and respiratory signals.Scientific reports · 2026Article
- Cerebral oxygen extraction fraction as an emerging imaging biomarker in mild cognitive impairment and dementia.Dementia & neuropsychologia · 2026Review
- Cerebral oxygen extraction across different exercise intensities: Role of arterialExperimental physiology · 2025Article
- Article
- Venous arterial spin labeling MRI signal is associated with oxygen supply-independent reduction in cerebral oxygen extraction in typically aging older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Toward vendor-independent measurement of cerebral venous oxygenation: Comparison of TRUST MRI across three major MRI manufacturers and association with end-tidal CONMR in biomedicine · 2023Article
- Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow.NeuroImage · 2023Article
- Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Cerebral oxygen extraction fraction MRI: Techniques and applications.Magnetic resonance in medicine · 2022Review
- Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Multi-Parametric Evaluation of Cerebral Hemodynamics in Neonatal Piglets Using Non-Contrast-Enhanced Magnetic Resonance Imaging Methods.Journal of magnetic resonance imaging : JMRI · 2021Article
- Effects of mild hypoxia on oxygen extraction fraction responses to brain stimulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded-OMagnetic resonance in medicine · 2021Article
- Brain Oxygenation in Post-concussion Combat Sport Athletes.Frontiers in sports and active living · 2021Article
- Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases.Journal of magnetic resonance imaging : JMRI · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Cerebral oxygen extraction fraction is an important physiological index of the brain's oxygen consumption and supply and has been suggested to be a potential biomarker for a number of diseases such as stroke, Alzheimer's disease, multiple sclerosis, sickle cell disease, and metabolic disorders. However, in order for oxygen extraction fraction to be a sensitive biomarker for personalized disease diagnosis, inter-subject variations in normal subjects must be minimized or accounted for, which will otherwise obscure its interpretation. Therefore, it is essential to investigate the physiological underpinnings of normal differences in oxygen extraction fraction. This work used two studies, one discovery study and one verification study, to examine the extent to which an individual's end-tidal CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.