ArticleAnimals : an open access journal from MDPI2019
Changes of Oxytocin and Serotonin Values in Dialysis Patients after Animal Assisted Activities (AAAs) with a Dog—A Preliminary Study.
Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Systematic Review and Meta-Analysis of the Occurrence of ESKAPE Bacteria Group in Dogs, and the Related Zoonotic Risk in Animal-Assisted Therapy, and in Animal-Assisted Activity in the Health Context.International journal of environmental research and public health · 2020Pooled it
- Guidance for protocol content and reporting of dog-assisted interventions in randomised controlled trials: explanation and elaboration of the SPIRIT 2025 and CONSORT 2025 extensions.BMC medical research methodology · 2026Article
- An overview of the benefits of animal-assisted interventions in medical and therapeutic contexts for human health: cognitive mechanisms, sensory perception and welfare considerations.Frontiers in veterinary science · 2026Review
- Animal Assisted Activities (AAAs) with Dogs in a Dialysis Center in Southern Italy: Evaluation of Serotonin and Oxytocin Values in Involved Patients.Biomedicines · 2025Article
- Specific Neural Mechanisms Underlying Humans' Processing of Information Related to Companion Animals: A Comparison with Domestic Animals and Objects.Animals : an open access journal from MDPI · 2025Article
- A bibliometric study for global hotspots and trends in animal-assisted interventions (1983-2023).Frontiers in psychiatry · 2025Review
- The Role of Animal-Assisted Therapy in Enhancing Patients' Well-Being: Systematic Study of the Qualitative and Quantitative Evidence.JMIRx med · 2024Review
- Human-Animal Interaction in Animal-Assisted Interventions (AAI)s: Zoonosis Risks, Benefits, and Future Directions-A One Health Approach.Animals : an open access journal from MDPI · 2023Review
- Characterizing stress during animal interaction: a focus on the human endocrine response during equine-assisted services.Frontiers in veterinary science · 2023Review
- Oxytocin levels and self-reported anxiety during interactions between humans and cows.Frontiers in psychology · 2023Article
- Molecular Biomarkers of Adult Human and Dog Stress during Canine-Assisted Interventions: A Systematic Scoping Review.Animals : an open access journal from MDPI · 2022Article
- Effects of Dog-Assisted Therapy in Adolescents with Eating Disorders: A Study Protocol for a Pilot Controlled Trial.Animals : an open access journal from MDPI · 2021Article
- Zoonotic Risk ofInternational journal of environmental research and public health · 2021Review
- An Animal-Assisted Education Intervention with Dogs to Promote Emotion Comprehension in Primary School Children-The Federico II Model of Healthcare Zooanthropology.Animals : an open access journal from MDPI · 2021Article
- Presence ofInternational journal of environmental research and public health · 2021Article
- Occurrence ofInternational journal of environmental research and public health · 2020Article
- Animal-Assisted Therapy as a Non-Pharmacological Approach in Alzheimer's Disease: A Retrospective Study.Animals : an open access journal from MDPI · 2020Article
- Methodological and Terminological Issues in Animal-Assisted Interventions: An Umbrella Review of Systematic Reviews.Animals : an open access journal from MDPI · 2020Review
- The Presence ofAnimals : an open access journal from MDPI · 2019Review
- The Human-Animal Relationship as the Focus of Animal-Assisted Interventions: A One Health Approach.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our study aimed to measure the levels of serotonin and oxytocin in patients affected by end-stage renal disease (ESRD), undergoing dialysis and participating in a program of animal-assisted activities (AAAs) with a dog. Ten patients with comparable levels of ESRD were enrolled. A blood sample was taken before the start of the study in order to establish basal levels. Eleven meetings were held once a week for 3 months during the last hour of dialysis, and blood samples were collected before and after AAAs. Two more meetings, one month apart from each other, were held two months later without the dog but with the same veterinarian zootherapist. Blood was drawn at the beginning and at the end of each meeting. The samples were then processed for the measurement of serotonin and oxytocin, and data obtained were analysed using analysis of variance with mixed effect models. The results show an increasing level of both serotonin and oxytocin between subsequent meetings with the dog and an increasing trend of inter-intervention levels. Overall, the results suggest that AAAs lead to modifications of serotonin and oxytocin levels, which are also accompanied by behavioural changes of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.