Evidence map›Paper›PMID 31382453›Full record

ArticleVaccines2019

Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.

Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Alex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. RecombinantVaccines · 2025
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  7. AuxotrophicVaccines · 2022
    Review
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  13. Review
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  15. Vaccine strategies for theNPJ vaccines · 2020
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Athina KilpeläinenCatalan Center for HIV Vaccine Research and Development, AIDS Research Unit, Infectious Diseases Department, Hospital Clínic/IDIBAPS, 08036 Barcelona, Catalonia, Spain.ORCID 0000-0003-4303-2443
Narcís SaubiCatalan Center for HIV Vaccine Research and Development, AIDS Research Unit, Infectious Diseases Department, Hospital Clínic/IDIBAPS, 08036 Barcelona, Catalonia, Spain.
Núria GuitartCatalan Center for HIV Vaccine Research and Development, AIDS Research Unit, Infectious Diseases Department, Hospital Clínic/IDIBAPS, 08036 Barcelona, Catalonia, Spain.
Alex OlveraIrsicaixa AIDS Research Institute, 08916 Badalona, Catalonia, Spain.
Tomáš HankeNuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Christian BranderIrsicaixa AIDS Research Institute, 08916 Badalona, Catalonia, Spain.
Joan JosephCatalan Center for HIV Vaccine Research and Development, AIDS Research Unit, Infectious Diseases Department, Hospital Clínic/IDIBAPS, 08036 Barcelona, Catalonia, Spain. jjoseph@vhebron.net.
Vall d'Hebron Institut de Recerca · ESUniversitat de Vic - Universitat Central de Catalunya · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversity of Oxford · GB

Funding

Horizon 2020 681137Instituto de Salud Carlos III FIS PI14/00494Instituto de Salud Carlos III RETIC-RIS RD12/0017Medical Research Council MR/N023668/1
6 · The paper itself

Abstract

Despite the availability of anti-retroviral therapy, HIV-1 infection remains a massive burden on healthcare systems. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, confers protection against meningitis and miliary tuberculosis in infants. Recombinant BCG has been used as a vaccine vehicle to express both HIV-1 and Simian Immunodeficiemcy Virus (SIV) immunogens. In this study, we constructed an integrative

Indexed as

BCGHIVHTIrBCGT-cellvaccine

Identifiers

PMID31382453
PMCPMC6789536
OpenAlexW2966731764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.