Evidence map›Paper›PMID 31382440›Full record

ArticleNutrients2019

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.

Ulla Uusitalo, Carin Andren Aronsson, Xiang Liu, Kalle Kurppa, Jimin Yang, Edwin Liu, Jennifer Skidmore, Christiane Winkler, Marian J Rewers, William A Hagopian and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023
    Review
  9. Review
  10. Current and emerging therapies for coeliac disease.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  11. Can Celiac Disease Be Prevented?Frontiers in immunology · 2021
    Review
  12. Review
  13. Review
  14. Microbiome of root vegetables-a source of gluten-degrading bacteria.Applied microbiology and biotechnology · 2020
    Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 4 countries.

Ulla UusitaloHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. ulla.uusitalo@epi.usf.edu.
Carin Andren AronssonThe Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden.ORCID 0000-0003-0256-9367
Xiang LiuHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Kalle KurppaTampere Center for Child Health Research, University of Tampere, 33014 Tampere, Finland.
Jimin YangHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Edwin LiuDigestive Health Institute, Children's Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA.
Jennifer SkidmorePacific Northwest Research Institute, Seattle, WA 98122, USA.
Christiane WinklerInstitute of Diabetes Research, Helmholtz Zentrum München, 85764 Munich-Neuherberg, Germany.
Marian J RewersBarbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045, USA.
William A HagopianPacific Northwest Research Institute, Seattle, WA 98122, USA.
Jin-Xiong SheMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Jorma ToppariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20014 Turku, Finland.ORCID 0000-0003-2228-334X
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, 85764 Munich-Neuherberg, Germany.
Beena AkolkarNIDDK, National Institute of Health, Bethesda, MD 20892, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA.
Suvi M VirtanenTampere Center for Child Health Research, University of Tampere, 33014 Tampere, Finland.
Jeffrey P KrischerHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Daniel AgardhThe Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden.ORCID 0000-0003-1435-1234
TEDDY Study Group
University of South Florida · USLund University · SEPacific Northwest Diabetes Research Institute · USTampere University · FITUM Klinikum · DEAugusta University · USChildren's Hospital Colorado · USColorado School of Public Health · USNational Institutes of Health · USUniversity of Colorado Denver · USUniversity of Turku · FI

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4M
The Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0M
Data Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0M
The Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5M
THE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
The Environmental Determinants of Diabetes in Youth: Washington Clinical CenterU01DK063829 · NIDDK · PACIFIC NORTHWEST RESEARCH INSTITUTE · PI HAGOPIAN, WILLIAM A. · 2003 to 2022
$11.8M
The Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2013 to 2013
$5.6M
NIDDK NIH HHS HHSN267200700014CNIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063863NIDDK NIH HHS U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483NIH HHS UL1 TR000064NIH HHS UL1 TR001082
6 · The paper itself

Abstract

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (

Indexed as

Autoimmune DiseasesCeliac DiseaseChildChild, PreschoolDietary SupplementsFemaleGenetic Predisposition to DiseaseGenotypeHLA AntigensHumansInfantInfant FormulaInfant, NewbornMaleProbioticsRisk FactorsHLA Antigensceliac diseaseceliac disease autoimmunitydietary supplementsinfant formulaprobiotics

Identifiers

PMID31382440
PMCPMC6722940
OpenAlexW2965503068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.