ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Reduced fractional anisotropy in depressed patients due to childhood maltreatment rather than diagnosis.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression.Brain and behavior · 2025Pooled it
- Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.Brain imaging and behavior · 2021Pooled it
- BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.Behavioural neurology · 2021Pooled it
- The role of white matter microstructure in the association between childhood maltreatment and adult post-traumatic symptoms.Molecular psychiatry · 2026Article
- Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.Nature communications · 2025Article
- Brain White Matter Alterations in Young Adults with Childhood Emotional Neglect Experience.Behavioral sciences (Basel, Switzerland) · 2025Article
- BDNF Gene Polymorphism and Antidepressant Response in Han Chinese Patients with First-Episode Late-Life Depression.Alpha psychiatry · 2025Article
- Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens.Psychological medicine · 2024Article
- Objective QC for diffusion MRI data: Artefact detection using normative modelling.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.Biological psychiatry global open science · 2024Article
- Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.Molecular psychiatry · 2023Article
- Familial risk for major depression: differential white matter alterations in healthy and depressed participants.Psychological medicine · 2023Article
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder.Molecular psychiatry · 2023Article
- Right amygdala-right precuneus connectivity is associated with childhood trauma in major depression patients and healthy controls.Social cognitive and affective neuroscience · 2023Article
- Long-term effect of childhood trauma: Role of inflammation and white matter in mood disorders.Brain, behavior, & immunity - health · 2022Article
- Distinct stress-related medial prefrontal cortex activation in women with depression with and without childhood maltreatment.Depression and anxiety · 2022Article
- Sex and sensitive period differences in potential effects of maltreatment on axial versus radial diffusivity in the corpus callosum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study.Molecular psychiatry · 2022Article
- White Matter Alterations in Depressive Disorder.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
25 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced fractional anisotropy (FA) associated with Major Depressive Disorder (MDD) overlaps anatomically with effects of childhood maltreatment experiences. The aim of this study was, therefore, to replicate the negative effect of childhood maltreatment on white matter fiber structure and to demonstrate, that alterations in MDD might be partially attributed to the higher occurrence of childhood maltreatment in MDD. Two independent cohorts (total N = 1 256) were investigated in a diffusion tensor imaging study: The Münster Neuroimaging Cohort (MNC, N = 186 MDD, N = 210 healthy controls, HC) as discovery sample and the Marburg-Münster Affective Disorders Cohort Study (MACS, N = 397 MDD, N = 462 HC) as replication sample. The effects of diagnosis (HC vs. MDD) and Childhood Trauma Questionnaire (CTQ) scores on FA were analyzed. A main effect of diagnosis with higher FA in MDD patients compared with HC was found in the MNC (p
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